18:19 , May 23, 2018 |  BC Innovations  |  Distillery Therapeutics

Transplant

INDICATION: Graft-versus-host disease (GvHD) Mouse studies suggest inhibiting DOT1L or overexpressing DUSP6 could help treat GvHD associated with T cell therapies. In a mouse model of xenogeneic T cell-associated GvHD, adoptive transfer of human CD8+...
19:17 , May 17, 2018 |  BC Extra  |  Preclinical News

Targeting DOT1L, DUSP6 to prevent GvHD

In a Nature Communications study, scientists at University Health Network and University of Toronto showed that inhibiting histone methyltransferase DOT1L or promoting dual specificity phosphatase 6 (DUSP6; MKP3) could help prevent graft-versus-host disease induced by...
17:39 , Jan 25, 2017 |  BC Innovations  |  Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Obesity Mouse studies suggest fecal microbiotal transplants from DUSP6-deficient donors could help treat obesity. In mice fed a high-fat diet, DUSP6 knockout decreased the permeability of gut epithelial cells and weight gain compared with normal...
00:30 , Jan 13, 2017 |  BC Innovations  |  Targets & Mechanisms

Gut control

As evidence mounts linking obesity to the microbiome, three independent studies have identified separate ways of harnessing gut microbiota to treat the condition. The spectrum of approaches, which involve a bacterial protein, a bacterial species...
07:00 , Oct 6, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Tumor protein p63 (TP63; p63); dual specificity phosphatase 6 (DUSP6; MKP3)

Cancer INDICATION: Cancer Patient sample, cell culture and mouse studies suggest inhibiting TP63 or DUSP6 could help treat p53-mutant cancers. In patients with p53-mutant breast cancer or head and neck squamous cell carcinoma (HNSCC), high tumor expression...
07:00 , Jul 16, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Dual specificity phosphatase 6 (DUSP6; MKP3)

Cancer INDICATION: Acute lymphoblastic leukemia (ALL) Mouse and patient sample studies suggest inhibiting DUSP6 could help treat ALL. In tumor samples from patients with ALL, high levels of DUSP6 correlated with poor overall survival. In B cells...
07:00 , Oct 14, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes Dual specificity phosphatase 6 (DUSP6; MKP3) A study in mice...