BioCentury | Aug 24, 2017
Translation in Brief

Unclumping TDP-43

Two studies published in Nature Communications have identified different features of TDP-43 that promote its aggregation in neurodegenerative disorders, and point to different therapeutic strategies for preventing or dissolving the clumps. Aggregation of TAR DNA...
BioCentury | May 11, 2017
Tools & Techniques

Stemming the tide

...lines compared with no treatment February 2013 DnaJ (Hsp40) homolog subfamily B member 8 (DNAJB8) Renal cancer In renal cancer cell lines, DNAJB8...
BioCentury | Oct 27, 2016
Translation in Brief

Blueprint for fusion

Blueprint Medicines Corp. (NASDAQ:BPMC) and researchers at The Rockefeller University are ramping up their collaboration to develop inhibitors of a disease-driving fusion protein found in all patients with fibrolamellar carcinoma, a rare subtype of hepatocellular...
BioCentury | Sep 25, 2014
Distillery Therapeutics

Indication: Endocrine/metabolic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Gaucher's disease DnaJ homolog subfamily B member 11 (DNAJB11; ERdj3); glucocerebrosidase (GBA; GCase) Mouse studies suggest inhibiting ERdj3 could help treat Gaucher's disease, a...
BioCentury | Mar 27, 2014
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Liver cancer DnaJ (Hsp40) homolog subfamily B member 1 (DNAJB1); protein kinase cAMP-dependent catalytic-a (PRKACA) Human sample and in vitro studies suggest inhibiting the DNAJB1-PRKACA...
BioCentury | Jun 7, 2012
Distillery Therapeutics

Indication: Cancer

...Publication and contact information Cancer Renal cancer DnaJ (Hsp40) homolog subfamily B member 8 (DNAJB8) In vitro and mouse studies suggest blocking DNAJB8...
...on cancer stem cells could help treat renal cell carcinoma. In renal carcinoma cell lines, anti-DNAJB8...
...stem cell population and decreased tumor-initiating ability compared with siRNA controls. In mice, immunization with Dnajb8...
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