18:57 , May 30, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Prostate cancer In vitro , cell culture and mouse studies suggest inhibiting the DNAJ/Hsp70 chaperone axis could help treat castration-resistant prostate cancer (CRPC). Screening of a library of chalcone analogs and testing in cell-based...
07:00 , Oct 27, 2016 |  BC Innovations  |  Translation in Brief

Blueprint for fusion

Blueprint Medicines Corp. (NASDAQ:BPMC) and researchers at The Rockefeller University are ramping up their collaboration to develop inhibitors of a disease-driving fusion protein found in all patients with fibrolamellar carcinoma, a rare subtype of hepatocellular...
07:00 , Sep 25, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine/metabolic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Gaucher's disease DnaJ homolog subfamily B member 11 (DNAJB11; ERdj3); glucocerebrosidase (GBA; GCase) Mouse studies suggest inhibiting ERdj3 could help treat Gaucher's disease, a...