BioCentury | Feb 14, 2020
Product Development

AML’s growing options

...c-Kit (KIT; CD117) - Stem cell factor (SCF) receptor tyrosine kinase CD33 (SIGLEC3) CD70 (CD27L) DNA methyltransferase...
BioCentury | Sep 12, 2019
Distillery Therapeutics

Inhibition of G9A and DNMT methyltransferases in bladder cancer

...Inc. and Opdivo nivolumab from Bristol-Myers Squibb Co. TARGET/MARKER/PATHWAY: Euchromatic histone-lysine N-methyltransferase 2 (EHMT2; G9A); DNA methyltransferase...
...fprosper@unav.es CONTACT: Jesús M. Paramio, CIEMAT, Madrid, Spain e-mail: jesusm.paramio@ciemat.es Inhua Muijrers-Chen Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) (G9A) DNA methyltransferase DNA...
BioCentury | Sep 6, 2019
Clinical News

Opdivo misses in latest GBM readout

...endpoints. The trial evaluated temozolomide and radiation therapy with and without Opdivo in newly diagnosed, O6-methylguanine-DNA methyltransferase...
BioCentury | May 17, 2019
Clinical News

AbbVie's antibody-drug conjugate misses mark in Phase III GBM trial

...Co. (NYSE:BMY) that PD-1 inhibitor Opdivo nivolumab failed a Phase III trial for newly diagnosed O6-methylguanine-DNA methyltransferase...
BioCentury | May 9, 2019
Clinical News

May 9 Clinical Quick Takes: Polyphor, BMS, Cel-Sci, University of Pittsburgh, Merck, Scholar Rock, Promethera

...vs. temozolomide plus radiation in the Phase III CheckMate -498 trial to treat newly diagnosed O6-methylguanine-DNA methyltransferase...
BioCentury | Aug 3, 2018
Clinical News

Otsuka's guadecitabine misses in Phase III for first-line AML

...to report data from both ASTRAL-2 and ASTRAL-3 in mid-2020. Guadecitabine is a small molecule DNA methyltransferase...
...Product: Guadecitabine (formerly SGI-110) Business: Cancer Molecular target: DNA (cytosine-5-)-methyltransferase 1 (DNMT1) Description: Small molecule DNA methyltransferase...
BioCentury | Jul 31, 2018
Clinical News

Otsuka's guadecitabine misses in Phase III for first-line AML

...to report data from both ASTRAL-2 and ASTRAL-3 in mid-2020. Guadecitabine is a small molecule DNA methyltransferase...
BioCentury | Jun 20, 2018
Distillery Techniques

Drug platforms

...plus the CRISPR-Cas12a system designed to introduce mutations into hypoxanthine phosphoribosyltransferase 1 (HPRT1; HGPRT) or DNA methyltransferase...
...Li Max Planck Institute for Evolutionary Anthropology CRISPR from Prevotella and Francisella 1 (Cas12a) (Cpf1) CRISPR-associated protein 9 (Cas9) DNA methyltransferase Hypoxanthine...
BioCentury | Apr 17, 2018
Distillery Techniques

Disease models; drug properties

...factor (EGF) to generate uniform spheroids; and differentiating them into intestinal tissue using inhibitors of DNA methyltransferase...
BioCentury | Apr 13, 2018
Company News

Novo Nordisk licenses sickle cell candidate from EpiDestiny

...develop EPI01 for oncology indications. EPI01 is an oral formulation of two small molecules -- DNA methyltransferase...
...Solon, Ohio Novo Nordisk A/S (CSE:NOVOB; NYSE:NVO), Bagsvaerd, Denmark Business: Hematology Mary Romeo Novo Nordisk A/S Cytidine deaminase (CDA) DNA methyltransferase EPI01 EpiDestiny...
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