...DNA gyrase could treat drug-resistant Staphylococcus aureus infections. In vitro , the compound inhibited S. aureus DNA gyrase... ...identified through a screen of synthetic small molecules previously reported to inhibit Gram-positive bacteria. TARGET/MARKER/PATHWAY: DNA gyrase... ...2, 2019 doi:10.1016/j.chembiol.2019.06.002 CONTACT: Justin Nodwell, University of Toronto, Toronto, Ontario email: email@example.com
University of Toronto
...advance the compound for TB. Financial terms were not disclosed. The biotech acquired SPR720, a DNA gyrase... ...resistance mechanisms (see "Bug Money" ).
Karen Tkach Tuzman, Associate Editor
Bill & Melinda Gates Foundation
Spero Therapeutics Inc.
...infection In vitro , cell culture, mouse, rat and dog studies identified a spiropyrimidinetrione-based bacterial DNA gyrase... ...assays of analogs of a previously reported spiropyrimidinetrione yielded a compound that inhibited S. aureus DNA gyrase... ...of systemic MRSA or MSSA infection, the compound prolonged survival with greater potency than the DNA gyrase...
...2013 deal. Linhaliq is a dual-release product consisting of a liposomal-encapsulated form of ciprofloxacin, a DNA gyrase... ...Barcelona, Spain Product: Linhaliq liposomal ciprofloxacin Business: Infectious disease
Linhaliq, liposomal ciprofloxacin (ARD-3150, pulmaquin)