BioCentury | Sep 12, 2019
Distillery Therapeutics

Inhibition of G9A and DNMT methyltransferases in bladder cancer

...CONTACT: Jesús M. Paramio, CIEMAT, Madrid, Spain e-mail: jesusm.paramio@ciemat.es Inhua Muijrers-Chen Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) (G9A) DNA methyltransferase DNA (cytosine-5-)-methyltransferase 1 (DNMT1) Phosphoinositide...
BioCentury | Apr 19, 2019
Company News

BioSense gets Asia rights to Rexahn's pancreatic cancer therapy

...by uridine cytidine kinase and inhibits DNA and RNA synthesis and mediates the down-regulation of DNA (cytosine-5-)-methyltransferase 1 (DNMT1)...
...has Orphan Drug designation in the U.S. and EU. Sandi Wong, Staff Writer RX-3117 BioSense Global LLC Rexahn Pharmaceuticals Inc. DNA (cytosine-5-)-methyltransferase 1 (DNMT1) Pancreatic...
BioCentury | Aug 3, 2018
Clinical News

Otsuka's guadecitabine misses in Phase III for first-line AML

...Otsuka Pharmaceutical Co. Ltd., Tokyo, Japan Product: Guadecitabine (formerly SGI-110) Business: Cancer Molecular target: DNA (cytosine-5-)-methyltransferase 1 (DNMT1)...
...III data Milestone: Phase III data (mid-2020) Jaime De Leon Guadecitabine (SGI-110, s110) Astex Pharmaceuticals Inc. Otsuka Pharmaceutical Co. Ltd. DNA (cytosine-5-)-methyltransferase 1 (DNMT1)...
BioCentury | Jul 31, 2018
Clinical News

Otsuka's guadecitabine misses in Phase III for first-line AML

...million in cash (see "Consolation Prize" ). Jaime De Leon Guadecitabine (SGI-110, s110) Astex Pharmaceuticals Inc. Otsuka Pharmaceutical Co. Ltd. DNA (cytosine-5-)-methyltransferase 1 (DNMT1)...
BioCentury | Dec 8, 2017
Targets & Mechanisms

Epiphenomena at ASH

...methyltransferase and histone deacetylases -- and compounds against a few less established targets, the methyltransferases DNMT1...
...CUB and Sushi multiple domains 3 CXCR4 (NPY3R) - CXC chemokine receptor 4 DNMT1 - DNA (cytosine-5-)-methyltransferase 1...
...2B4 (CD244) (2B4) CD3zeta (CD3z) (CD247) CD7 molecule (CD7) Checkpoint kinase 1 (Chk1) (CHEK1) CXC chemokine receptor 4 (CXCR4) (NPY3R) DNA (cytosine-5-)-methyltransferase 1 (DNMT1) Enhancer...
BioCentury | Oct 3, 2017
Distillery Therapeutics

Cancer

...mouse studies suggest inhibiting DNMT1 could help treat gastric cancer. In patients, high levels of DNMT1...
...a xenograft mouse model of gastric cancer, the DNA methyltransferase inhibitor Dacogen decitabine or a DNMT1...
...inhibitor tool compound decreased tumor growth compared with no treatment. Next steps could include testing DNMT1...
BioCentury | Sep 21, 2017
Tools & Techniques

On your marks

...epigenetic targets are being pursued in the clinic, including the demethylase LSD1 and the methyltransferases DNMT1...
...AKT (AKT1; PKB; PKBA) - Protein kinase B BRD4 - Bromodomain containing 4 DNMT1 - DNA (cytosine-5-)-methyltransferase 1...
BioCentury | Jun 7, 2017
Distillery Therapeutics

Cancer

...myelogenous leukemia (AML); B cell lymphoma Cell culture and mouse studies identified an aminoquinoline-based dual DNMT1...
...AML, the compound increased survival compared with vehicle. Next steps could include testing the dual DNMT1/EHMT2...
...testing for chronic lymphocytic leukemia (CLL) and Phase I testing for B cell lymphoma. TARGET/MARKER/PATHWAY: DNA (cytosine-5-)-methyltransferase 1 (DNMT1)...
BioCentury | May 16, 2017
Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer In vitro and cell culture studies identified a quinolone-quinazoline conjugate-based DNMT3A inhibitor that could help treat colorectal cancer. Chemical synthesis and testing of quinolone-quinazoline conjugate analogs in vitro yielded a compound that...
BioCentury | May 11, 2017
Tools & Techniques

Stemming the tide

...of metastases in mice compared with either agent alone March 2017 DNA (cytosine-5-)-methyltransferase 1 (DNMT1) Pancreatic cancer Blocking DNMT1...
Items per page:
1 - 10 of 55