BioCentury | Oct 2, 2014
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer; prostate cancer Insulin-like growth factor-1 receptor (IGF1R; CD221); dishevelled segment polarity protein 3 (DVL3) Studies in vitro and in human samples suggest IGF1R...
BioCentury | Mar 14, 2013
Targets & Mechanisms

Placing kinases in the WNT pathway

Despite the well-established role of WNT signaling in many cancers, the pathway has proven difficult to modulate therapeutically because it is largely composed of hard-to-target protein-protein interactions. Now, a Boston-based team and a group led...
BioCentury | Jun 30, 2011
Distillery Therapeutics

Indication: Neurology

...Depression Dishevelled dsh homolog1 (DVL1; DVL); glycogen synthase kinase 3 (GSK3) Mouse studies suggest increasing DVL...
...treat depression. In mice susceptible to depression and in postmortem brain tissue from depression patients, DVL...
...levels were lower than those in controls. In the mouse model, overexpression of Gsk3 decreased Dvl...
Items per page:
1 - 3 of 3