BioCentury | Jul 19, 2019
Regulation

A half step forward for heart failure as FDA guidance leaves key question unanswered

...example, safety profiles of ACE inhibitors, angiotensin receptor blockers, mineralocorticoid receptor antagonists, beta blockers and digoxin...
BioCentury | Nov 28, 2018
Preclinical News

Placental organoid could improve preeclampsia therapies

...subsidiary of LFB S.A. (Les Ulis, France); and DIF, a polyclonal antibody fragment that neutralizes digoxin...
...Velo Bio LLC (Morrisville, N.C.) and Glenveigh Medical LLC (Chattanooga, Tenn.). Mark Zipkin ATryn (rhAT) DIF, Digibind, DigiFab, digoxin...
BioCentury | Oct 31, 2018
Distillery Therapeutics

Cancer

...INDICATION: Brain cancer In silico , cell culture and mouse studies suggest digoxin could help treat...
...testing of the top 100 hits in a human group 3 medulloblastoma cell line, yielded digoxin...
...with radiation alone. Next steps could include identifying digoxin’s molecular target in medulloblastoma. The generic digoxin...
BioCentury | Jun 9, 2017
Clinical News

Velo begins Phase IIb/III for digoxin immune fab to treat severe preeclampsia

...said Velo Bio LLC (Morrisville, N.C.) began a double-blind, U.S. Phase IIb/IIIa trial to evaluate digoxin...
...submit an NDA to FDA in 2019. Patients will receive placebo or 3.2 mg/kg IV digoxin...
...DIF , DigiFab) Business: Genitourinary Molecular target: Digoxin Description: Polyclonal antibody fragment that neutralizes digoxin...
BioCentury | Oct 13, 2016
Distillery Therapeutics

Therapeutics: MEK; BRAF

...acute myelogenous leukemia (AML) Patient sample, cell culture and mouse studies suggest combining digitoxin or digoxin...
...help treat melanoma and AML. In primary tumor cells from three melanoma patients, digitoxin or digoxin...
...Tafinlar , Mekinist and digoxin decreased tumor growth compared with Tafinlar plus Mekinist, Tafinlar plus digoxin...
BioCentury | Jun 23, 2016
Tools & Techniques

Home is in the placenta

...preeclampsia Phase III Glenveigh Medical LLC Digibind digoxin immune fab Polyclonal antibody fragment that neutralizes digoxin...
BioCentury | Apr 21, 2016
Product R&D

A1M for preeclampsia

...and Glenveigh Medical LLC has Digibind digoxin immune fab, a polyclonal antibody fragment that neutralizes digoxin...
...for deep vein thrombosis (DVT) and approved for antithrombin deficiency. Digibind is approved for treating digoxin...
...and tissue damage Disease Preeclampsia; acute kidney injury (AKI) Competition ATryn recombinant human antithrombin; Digibind digoxin...
BioCentury | Mar 16, 2015
Company News

Covis, Concordia Healthcare deal

...Nilandron nilutamide, a testosterone blocker that is marketed to treat prostate cancer; cardiovascular drug Lanoxin digoxin...
BioCentury | Nov 20, 2014
Distillery Therapeutics

Indication: Neurology

...In a mouse model of ALS, RNAi knockdown of Add1 or Atp1a2 or treatment with digoxin-an...
...vehicle treatment. Next steps could include identifying specific inhibitors of the ADD1-ATP1A2 complex. The generic digoxin...
BioCentury | Jul 24, 2014
Distillery Therapeutics

Indication: Ophthalmic disease

...In vitro studies identified perhydro-1,4-oxazepine derivatives of digoxin that inhibited ATP1A2 with higher selectivity than digoxin...
...the lead ATP1A2 inhibitor was more effective at preventing chemical-induced elevation of intraocular pressure than digoxin...
Items per page:
1 - 10 of 78