16:58 , May 31, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Cell culture and mouse studies identified a JAG2 -targeting MT-TL1 fragment that could help treat colorectal cancer. The fragment consisted of a dicer 1 ribonuclease type III (DICER1)-cleaved form of MT-TL1 and...
07:00 , Jun 30, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Dicer 1 ribonuclease type III (DICER1); programmed cell death 1 (PD-1; PDCD1; CD279); CD40

Cancer INDICATION: Cancer Mouse studies suggest macrophage-specific inhibition of DICER1 could help treat cancer. In an orthotopic mouse model of breast cancer and a mouse model of lung cancer, DICER1 knockout in macrophages decreased primary...
07:00 , Aug 8, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer MicroRNA-21 (miR-21) In vitro and mouse studies suggest inhibiting miR-21 could help treat cancer. High throughput virtual screening identified a molecule that blocked the...
07:00 , May 17, 2012 |  BC Innovations  |  Cover Story

Eyeing the inflammasome

Two academic teams have independently shown that targeting the inflammasome reduces retinal damage in mouse models of age-related macular degeneration. 1,2 One study favors inhibiting inflammasome activation to treat dry AMD, whereas the other suggests...
08:00 , Mar 1, 2012 |  BC Innovations  |  Distillery Techniques

Technology: Disease models

Approach Summary Licensing status Publication and contact information Disease models Mouse model of serous ovarian cancer A mouse model of high-grade serous ovarian cancer could help identify biomarkers or therapeutics to treat the disease. Female...
08:00 , Feb 24, 2011 |  BC Innovations  |  Cover Story

Geography lesson in dry AMD

American researchers have identified an RNA-based mechanism in the retina that could be responsible for triggering the blindness associated with advanced dry age-related macular degeneration. 1 The team is developing inhibitors and ultimately hopes to...
08:00 , Feb 17, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Ophthalmic disease Age-related macular degeneration (AMD); blindness Alu RNA; dicer 1 ribonuclease type III (DICER1) Studies in patient samples and in mice suggest that decreasing...