BioCentury | Aug 20, 2020
Regulation

Pandemic could give advantage to newly approved MS latecomer ofatumumab

...head-to-head comparison with Aubagio teriflunomide, the mAb has a similar safety profile to the oral DHODH...
BioCentury | Aug 13, 2020
Finance

F2G raises $60.8M to get new class of antifungal to market

...or 1Q21, according to ClinicalTrials.gov. The U.K. and Austria-based company hopes to launch the fungal DHODH...
...at least $196.5 million. The company series of the round is undisclosed. TARGETSFungal DHODH – Fungal dihydroorotate dehydrogenase Stephen...
BioCentury | Aug 11, 2020
Product Development

Remdesivir heads for FDA review as Gilead continues to build manufacturing pipeline

...through a follow-on and $200 million through the sale of convertible senior notes due in 2026.PTC’s DHODH...
...companies,  global health agencies, academic institutions, philanthropic organizations and governments.TARGETSCRP - C-reactive protein DHODH - Dihydroorotate dehydrogenase...
...IAVI) Wellcome Trust Mannan binding lectin serine peptidase 2 (MASP2) Interleukin-6 (IL-6) Interleukin-8 (IL-8) (CXCL8) C-reactive protein (CRP) Lactate dehydrogenase (LDH) Dihydroorotate dehydrogenase (DHODH) Interleukin-17A...
BioCentury | Aug 4, 2020
Product Development

Aug. 3 Quick Takes: CymaBay gains on PBC readout; plus expanded labels for Epidiolex, Spravato, Voyager-AbbVie deal ends, Immunic and more

...the multiple sclerosis candidate met the primary endpoint of the Phase II EMPhASIS trial. The DHODH...
...and is eligible for milestones, plus royalties. Financial terms are not disclosed. Targets DHODH - Dihydroorotate dehydrogenase...
BioCentury | Jun 20, 2020
Deals

Clinical scorecard for COVID-19: lessons from the first wave of controlled trials

...efficacy have been seen in small, controlled trials of two other immunosuppressants: Arava leflunomide, a DHODH...
...I trial to treat COVID-19, and Immunic AG and Panoptes Pharma GmbH each have a DHODH...
BioCentury | May 23, 2020
Translation in Brief

A three-compound dengue treatment; plus reversing antibiotic resistance, AbCellera-Lilly, reducing cholesterol with CRISPR and COVID cash for Sherlock

...scientists combined two host-targeted compounds with a virus-targeted compound to yield potent dengue treatment. A DHODH...
...Cpf1) - CRISPR from Prevotella and Francisella 1 Cas13 - CRISPR-associated protein 13 DHODH - Dihydroorotate dehydrogenase...
...Philanthropy Project Stanford University Proprotein convertase subtilisin/kexin type 9 (PCSK9) CRISPR from Prevotella and Francisella 1 (Cas12a) (Cpf1) Dihydroorotate dehydrogenase (DHODH) COVID-19 Lilly AbCellera...
BioCentury | May 15, 2020
Product Development

Repurposed autoimmune therapies head for controlled COVID-19 studies in Europe

...Wednesday by Germany to start an adaptive Phase II trial of IMU-838, a selective oral DHODH...
...site (see “Fine-Tuning Therapeutic Protein Expression” ). Targets CBC - Cap binding complex DHODH - Dihydroorotate dehydrogenase...
BioCentury | Dec 3, 2019
Financial News

Dec. 2 Financial Quick Takes: Kodiak gains on royalty deal; plus Clover, Aslan, Transcenta, EOC, Hui-Gene and ViGeneron

...to treat eczema. The company also said last week that published preclinical data show its DHODH...
...spin-off is engineering adeno-associated viral vectors for delivery of ophthalmic gene therapies. Targets: DHODH - Dihydroorotate dehydrogenase...
BioCentury | Nov 19, 2019

Combining Arava with HIF1A inhibition to treat RA

...DHODH inhibitor that blocks pyrimidine synthesis, for RA. TARGET/MARKER/PATHWAY: Hypoxia-inducible factor 1α (HIF1A; HIF1-α); Dihydroorotate dehydrogenase (DHODH...
...2019 doi:10.1038/s41467-019-12163-z CONTACT: Ge Zhang, Hong Kong Baptist University, Hong Kong, China email: zhangge@hkbu.edu.hk Claire Quang Dihydroorotate dehydrogenase (DHODH) Hypoxia-inducible...
BioCentury | Sep 11, 2019
Product Development

Pharmas’ challenge: learning from rare disease units while leaving them alone

...MS) drugs Aubagio teriflunomide in 2012 and Lemtrada alemtuzumab in 2014. Aubagio is a dihydroorotate dehydrogenase (DHODH...
...Pharmaceutical Co. Ltd. (JASDAQ:4502; NYSE:TAK), Tokyo, Japan Yumanity Therapeutics LLC, Cambridge, Mass. Targets DHODH -- dihydroorotate dehydrogenase...
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