BioCentury | Aug 23, 2018
Distillery Therapeutics

Neurology

...sclerosis (ALS) In vitro , cell culture and mouse studies identified an inhibitor of the SOD1-DERL1...
...the compound in additional animal models of ALS. TARGET/MARKER/PATHWAY: Superoxide dismutase 1 (SOD1); der1-like domain family member 1 (DERL1; Derlin-1...
...CONTACT: Hidenori Ichijo, The University of Tokyo, Tokyo, Japan email: ichijo@mol.f.u-tokyo.ac.jp Mark Zipkin University of Tokyo Der1-like domain family member 1 (DERL1) (Derlin-1) Superoxide...
BioCentury | Jun 26, 2008
Distillery Therapeutics

This Week in Therapeutics

...status Publication and contact information Neurology Amyotrophic lateral sclerosis (ALS) Apoptosis signal-regulating kinase 1 (ASK1); ^derlin-1...
...mouse spinal cord neurons with a peptide to prevent binding of mutant SOD1 protein to derlin-1...
...SOD1 protein-induced cell death compared with those in untreated mice. Next steps include evaluating the derlin-1-binding...
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