BioCentury | Sep 2, 2020
Product Development

COVID-19 Quick Takes: NAS framework on vaccine allocation prioritizes higher risk groups

Framework to allocate vaccinesA discussion draft of a framework on equitable allocation of COVID-19 vaccines released by The National Academies of Sciences, Engineering and Medicine proposes...
BioCentury | Apr 22, 2019
Distillery Therapeutics

Targeting NETs with DNASE1 in pneumococcal meningitis

...INDICATION: Pneumococcus; meningitis Patient sample and rat studies suggest inhibiting neutrophil extracellular traps (NETs) with DNASE1...
...neurological conditions. In a rat model of subarachnoid pneumococcal meningitis, intrathecal or IV injection of DNASE1...
...Next steps could include testing DNASE1 for toxicity in animal models of pneumococcal meningitis. TARGET/MARKER/PATHWAY: Deoxyribonuclease I (DNASE1)...
BioCentury | Feb 1, 2019
Politics, Policy & Law

Trading blows over trade secrets

Roche’s Genentech Inc. unit kept an employee on the payroll in its South San Francisco office for almost a year after it discovered she was stealing trade secrets, watching as she channeled proprietary data to...
BioCentury | Aug 16, 2018
Distillery Techniques

Assays and screens; drug properties

TECHNOLOGY: Cellular assays; toxicology Human kidney cells cultured on decellularized rat kidney extracellular matrix (ECM) scaffolds could be used to screen compounds for nephrotoxicity. The method involved treating rat kidney tissue samples with detergent and...
BioCentury | Mar 29, 2018
Tools & Techniques

Cutting-edge diagnostics

Following the splash that CRISPR has made in the world of therapeutics, academics are expanding the tool kit of Cas enzymes and finding new uses in diagnostics. Early hints suggest the technology could become competitive,...
BioCentury | Dec 13, 2017
Distillery Techniques

Disease models

...personalized medicine applications. The organoids are generated by treating patient tumor samples with collagenase and deoxyribonuclease I (DNASE1)...
...13, 2017 doi:10.1038/nm.4438 CONTACT: Meritxell Huch, University of Cambridge, Cambridge, U.K. email: m.huch@gurdon.cam.ac.uk783 Hongjiang Li Mekinist Tafinlar University of Cambridge Collagenase Deoxyribonuclease I (DNASE1) MAP...
BioCentury | Nov 9, 2017
Targets & Mechanisms

Vesicular fuel

A study from Memorial Sloan Kettering Cancer Center has shown for the first time that fibroblasts can cause drug resistance by revving up the metabolism of dormant cancer cells. But the authors’ proposal that exosomes...
BioCentury | Feb 10, 2017
Clinical News

Alidornase alfa: Interim Ph II data

...AIR DNase) (PRX-110) Business: Pulmonary Molecular target: Deoxyribonuclease I (DNASE1) Description: Plant cell-derived recombinant form of human DNASE1...
...Status: Interim Ph II data Milestone: Additional Phase II data (1Q17) Julian Zhu AIR DNase alidornase alfa PRX-110 Protalix BioTherapeutics Inc. Deoxyribonuclease I (DNASE1)...
BioCentury | Dec 30, 2016
Clinical News

AIR DNase: Completed Ph II enrollment

...AIR DNase (PRX-110) Business: Pulmonary Molecular target: DNA Description: Plant cell-derived recombinant form of human deoxyribonuclease I (DNASE1)...
BioCentury | Nov 9, 2016
Distillery Therapeutics

Cancer

...Patient sample, cell culture and mouse studies suggest inhibiting neutrophil extracellular trap s (NETs) with DNASE1...
...metastatic tumors. In a human breast cancer cell line co-cultured with neutrophils, the NET-digesting enzyme DNASE1...
...cell invasiveness compared with vehicle. In a mouse mammary cancer cell line co-cultured with neutrophils, DNASE1...
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