BioCentury | Jun 20, 2018
Distillery Therapeutics

Infectious disease

...INDICATION: Staphylococcus Cell culture studies suggest inhibiting adenosine kinase, DCK or SLC29A1 could help treat Staphylococcus...
...knockout of adenosine kinase, DCK or SLC29A1 decreased cell death compared with normal adenosine kinase, DCK...
...oral small molecule DCK inhibitor, in preclinical testing to treat hematologic malignancies. TARGET/MARKER/PATHWAY: Adenosine kinase; deoxycytidine kinase (DCK)...
BioCentury | Jun 25, 2015
Product R&D

Cellectis' UCART-ography

...thinking about future products or variants for AML. For one, it plans to delete the DCK...
...College, New York, N.Y. Targets and Compounds CD123 - Interleukin-3 (IL-3) receptor α DCK - Deoxycytidine kinase...
...TCR - T cell receptor; TCRA - T cell receptor α chain; DCK - Deoxycytidine kinase...
BioCentury | Apr 30, 2015
Distillery Techniques

Techniques: Deoxycytidine kinase (DCK)-based in vivo PET imaging of T cell immunotherapies

...antigen receptor (CAR) and other T cell immunotherapies. Cells expressing a triple mutant of human DCK...
...model of melanoma receiving the imaging agent, human T cells engineered to express the mutant DCK...
...testing the mutant DCK-based PET imaging approach in clinical trials of T cell immunotherapies. DESCRIPTION: Deoxycytidine kinase (DCK)-based...
BioCentury | Apr 14, 2014
Finance

Double vision

...gemcitabine's three primary resistance mechanisms. It enters cells independently of nucleoside transporters, does not require deoxycytidine kinase (DCK)...
BioCentury | Apr 3, 2014
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Acute lymphocytic leukemia (ALL) Deoxycytidine kinase (DCK) In...
...nucleotide salvage pathway. In human T cell ALL lines, the combination of dT plus a DCK...
...and toxicology. SciBX 7(13); doi:10.1038/scibx.2014.364 Published online April 3, 2014 Patent application filed for the DCK...
BioCentury | Sep 19, 2013
Distillery Therapeutics

Indication: Cancer

...Cancer Deoxycytidine kinase (DCK) Mouse and in vitro studies identified DCK inhibitors that could help treat cancer. DCK...
...chemotherapy resistance. High throughput screening, SAR studies and cell-based assays identified small molecules that inhibit DCK...
...nanomolar IC50 values. In a mouse xenograft model of human leukemia, the lead inhibitor decreased DCK...
BioCentury | Dec 22, 2003
Product Development

Around the circle

..."CYC682 may be particularly active in tumors with a low ratio of cytidine deaminase to deoxycytidine kinase...
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