BioCentury | Nov 15, 2019
Company News

Roche adds to fibrosis portfolio with $390M Promedior acquisition

...on an option to acquire the biotech last year. The takeout gives Roche (SIX:ROG; OTCQB:RHHBY) PRM-151...
...of a Phase II trial that showed that in patients who switched from placebo to PRM-151...
...forced vital capacity (FVC) was reduced from -8.7% per year on placebo to -0.9% on PRM-151...
BioCentury | May 21, 2019
Clinical News

May 21 Clinical Quick Takes: Array gains on colorectal cancer plans; plus Tocagen, Promedior

...is overall survival and a final analysis is due to report by year end. Promedior's PRM-151...
...Promedior Inc. (Lexington, Mass.) reported data from an open-label extension of the 28-week Phase II PRM-151-202...
...treat idiopathic pulmonary fibrosis (IPF) showing a sustained benefit in patients who continued treatment with PRM-151...
BioCentury | Feb 14, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: January 2019

...Powassan virus protein prM Mouse studies suggest an mRNA vaccine based on Powassan virus protein prM...
BioCentury | Jan 3, 2019
Distillery Therapeutics

Infectious disease

...INDICATION: Viral infection Mouse studies suggest an mRNA vaccine based on Powassan virus protein prM and...
...The vaccine consists of a lipid nanoparticle loaded with a single mRNA encoding both protein prM...
...include testing the vaccine in mice challenged with other tick-borne flaviviruses. TARGET/MARKER/PATHWAY: Powassan virus protein prM...
BioCentury | Oct 4, 2018
Distillery Therapeutics

Infectious disease

...INDICATION: Zika virus Mouse studies suggest a vaccine based on Zika NS1, Env and prM could...
...virus non-structural protein NS1 (Zika NS1); Zika virus envelope protein (Env); Zika virus pre-membrane protein (prM...
...State University Zika virus envelope protein (Env) Zika virus non-structural protein NS1 (Zika NS1) Zika virus pre-membrane protein (prM) Zika...
BioCentury | Apr 18, 2018
Distillery Therapeutics

Infectious disease

...of seven viral antigens encoded by an attenuated Copenhagen strain vaccinia viral vector: Zika virus prM...
...models of Zika and Chikungunya. TARGET/MARKER/PATHWAY: Zika virus envelope protein (Env); Zika virus pre-membrane protein (prM...
...Ltd. University of South Australia Chikungunya virus structural polyprotein (CHIKVgp2) Zika virus envelope protein (Env) Zika virus pre-membrane protein (prM) Zika...
BioCentury | Dec 22, 2017
Product R&D

Dengvaxia’s warning

...of different approaches. Like Dengvaxia, some use a chimeric vaccine substituting the virus’ precursor-membrane protein (prM...
...Chimeric tetravalent vaccine consisting of live attenuated yellow fever virus 17D strain with dengue virus prM...
...Tokyo:4502), Osaka, Japan Uniformed Services University of the Health Sciences, Bethesda, Md. Targets prM - Dengue virus precursor-membrane protein...
BioCentury | Jul 19, 2017
Preclinical News

Vaccines protect against fetal Zika transmission

...given two doses of mRNA-1325 , a lipid-encapsulated modified mRNA vaccine encoding Zika Env and prM...
BioCentury | Feb 24, 2017
Product R&D

Two firsts for Zika

...89% of controls had detectable viremia. First, both contain RNAs encoding the virus’ Env and prM...
...Washington University in St. Louis, St. Louis, Mo. Targets Env - Zika virus envelope protein prM...
BioCentury | Feb 23, 2017
Distillery Therapeutics

Infectious disease

...infection. One vaccine consisted of lipid nanoparticles (LNPs) loaded with RNAs encoding Zika Env and prM...
...properties. The second vaccine consisted of LNPs loaded with a single RNA encoding Env and prM...
...see “Two Firsts for Zika”). TARGET/MARKER/PATHWAY: Zika virus envelope protein (Env); Zika virus pre-membrane protein (prM...
Items per page:
1 - 10 of 128