...INDICATION: Infectious Cell culture and mouse studies suggest inhibiting DC-SIGN could help treat schistosomiasis. In spleen...
...identifying and testing inhibitors of DC-SIGN in cell samples from schistosomiasis patients. TARGET/MARKER/PATHWAY: Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209...
...email: parisa.kalantari@tufts.edu CONTACT: Miguel J. Stadecker, same affiliation as above email: miguel.stadecker@tufts.edu Hongjiang Li Tufts University Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) (CD209...

...envelope proteins derived from the Sindbis virus that bind to the dendritic cell-specific ICAM-3 grabbing nonintegrin ( DC-SIGN ; CD209...
...Immune Design modified the envelope proteins for increased selectivity for dendritic cells and avidity for DC-SIGN...
...in envelope proteins derived from the Sindbis virus that bind the dendritic cell-specific ICAM-3 grabbing nonintegrin ( DC-SIGN ; CD209...

...Infectious disease INDICATION: Ebola Cell culture studies identified a DC-SIGN-binding glycofullerene that could help treat Ebola...
...In an infectivity assay in a DC-SIGN-expressing human T cell line, the compound competed for DC-SIGN...
...steps include optimizing and testing the molecule in animal models of Ebola. TARGET/MARKER/PATHWAY: Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209...

...Pulmonary disease INDICATION: Pulmonary fibrosis Mouse studies suggest activating DC-SIGN could help treat pulmonary fibrosis and...
...fibrotic diseases. In a mouse model of acute lung inflammation, a small molecule activator of DC-SIGN...
...small molecules and antibodies that activate DC-SIGN for use in human studies. TARGET/MARKER/PATHWAY: Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209...

...President and CEO Carlos Paya said the vector binds directly to dendritic cell-specific ICAM-3 grabbing nonintegrin ( DC-SIGN ; CD209...

...Publication and contact information Inflammation Inflammation Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209) Cell culture and mouse studies identified DC-SIGN-binding...
...units of varying length. In lipopolysaccharide (LPS)-stimulated human dendritic cells, the mannodendrimers selectively bound to DC-SIGN...

...he said. These other receptors include dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin ( DC-SIGN ; CD209...

...Sindbis viral glycoprotein engineered to target the dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin protein ( DC-SIGN...
...his group chose DC-SIGN in part because other researchers had shown that the C-type lectin DC-SIGN...
...lentivector to DCs. Moreover, Wang said, the glycoprotein could be engineered to bind exclusively to DC-SIGN...

...using a lentivector coated with a glycoprotein engineered to specifically bind the DC surface protein DC-SIGN...

...independently of gp120 binding to dendritic cell-specific ICAM-3-grabbing nonintegrin ( DC-SIGN ; CD209 ) . DC-SIGN...
...vitro studies is that effective microbicides should block interactions of gp120 with both SDC3 and DC-SIGN...
...is a seminal finding-not necessarily 'the' seminal finding, since it follows on the work on DC-SIGN...