21:01 , Nov 9, 2016 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Alzheimer's disease (AD) Mouse studies suggest inhibiting DAPK1 could help treat AD. In a mouse model of AD, expression of mutant DAPK1 lacking a catalytic or protein-binding domain in neurons of the entorhinal cortical...
07:00 , Aug 6, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Death-associated protein kinase 1 (DAPK1; DAPK)

Cancer INDICATION: Breast cancer In vitro and mouse studies suggest inhibiting DAPK1 could help treat p53-mutant, triple-negative breast cancer (TNBC). In p53-mutant TNBC cell lines, DAPK1 shRNA or a DAPK1 inhibitor decreased growth compared with...
08:00 , Mar 6, 2014 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Knockdown of endogenous proteins by peptide-directed lysosomal degradation Rat studies suggest a chaperone-mediated autophagy-targeting motif (CTM) that directs proteins toward lysosomal degradation could provide a...