BioCentury | May 23, 2017
Distillery Therapeutics

Cancer

...inhibiting DAXX could help treat PTEN -deficient glioblastoma multiforme (GBM). In PTEN-deficient neurospheres from patients, DAXX...
...of newly formed spheres compared with normal expression. In a xenograft mouse model of GBM, DAXX...
...wild-type tumors. Next steps could include identifying and testing DAXX inhibitors in GBM models. TARGET/MARKER/PATHWAY: Death-domain associated protein (DAXX)...
BioCentury | Jan 18, 2017
Distillery Therapeutics

Cancer

...INDICATION: Lung cancer Patient sample, cell culture and mouse studies suggest promoting DAXX expression could help...
...DAXX expression. In a xenograft mouse model of SNAI2-overexpressing lung cancer, mice, tumor overexpression of DAXX...
...number of lung metastases. Next steps could include identifying a therapeutic that upregulates DAXX. TARGET/MARKER/PATHWAY: Death-domain associated protein (DAXX)...
BioCentury | Feb 24, 2011
Distillery Therapeutics

Indication: Cancer

...Publication and contact information Cancer Pancreatic cancer; neuroendocrine tumors Multiple endocrine neoplasia I (MEN1; menin); death-domain associated protein (DAXX)...
...pancreatic neuroendocrine tumors. In pancreatic neuroendocrine tumors isolated from patients, mutation rates for the MEN1, DAXX...
...14% mutation rate. In patients with pancreatic neuroendocrine tumors, MEN1 mutations together with ATRX or DAXX...
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