08:00 , Dec 11, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Hepatic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Hepatic disease Liver disease Cytochrome P450 family 2 subfamily E polypeptide 1 (CYP2E1) Mouse studies suggest the plant-derived natural compound demethyleneberberine could help treat alcoholic liver...
07:00 , Jun 5, 2014 |  BC Innovations  |  Cover Story

Alas, porphyria

For over two decades, treatment of acute porphyrias has relied on hemin infusions that restore heme levels, but the therapy is slow to work, has side effects and is expensive. Now, a team led by...
07:00 , Aug 4, 2011 |  BC Innovations  |  Tools & Techniques

Metabolically, man or mouse

Massachusetts researchers have created mice with human ectopic artificial livers that were used to evaluate human drug metabolism, drug-drug interactions and drug-induced liver injury in a proof-of-principle study. 1 Unlike animal models that are currently...