BC Innovations | Feb 20, 2019
Distillery Techniques

Disease models; drug properties

TECHNOLOGY: Transgenics and knockouts; pharmacokinetics/pharmacodynamics Rats expressing human UGT2 or CYP3A gene clusters could be used to predict the PK of drug compounds metabolized by the two enzyme families. Rats engineered to express the entire...
BC Innovations | Apr 13, 2018
Targets & Mechanisms

Meeting the burden

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...
BC Innovations | Mar 24, 2016
Distillery Therapeutics

Therapeutics: Cytochrome P450 3A5 (CYP3A5)

Cancer INDICATION: Pancreatic cancer Patient sample and mouse studies suggest inhibiting CYP3A5 could help treat drug-resistant pancreatic ductal adenocarcinoma (PDAC). In patient-derived PDAC cell lines, high expression of CYP3A5 in one cell subtype was associated...
BC Week In Review | Jul 13, 2009
Clinical News

Genomas preclinical data

Genomas Inc. , Hartford, Conn.   Product: SINM PhyzioType System   Indication: Predict risk of statin-induced neuromyopathy   Based on blood samples from 442 subjects on statin treatment, the company characterized 384 SNPs from 222 cardiometabolic...
BC Week In Review | Jan 26, 2009
Clinical News

Clopidogrel cardiovascular data

Researchers from the Universite Pierre et Marie Curie and colleagues published in The New England Journal of Medicine data from the French FAST-MI trial showing that clopidogrel-treated patients carrying 2 CYP2C19 loss-of-function alleles and at...
BC Week In Review | Jul 29, 2002
Company News

Variagenics, St. Jude Children's Research Hospital deal

VGNX licensed from St. Jude a patent application covering the use of CYP3A5 genotyping technology to develop diagnostic kits predictive of drug response based on variable expression of CYP3A5. Under the terms of the agreement,...
BC Week In Review | Apr 2, 2001
Company News

St. Jude Children's Research Hospital other research news

St. Jude researchers published data in Nature Genetics showing that a SNP in the CYP3A5 gene was associated with significant levels of CYP3A5 in the liver and small intestine. The enyzme is involved in the...
BioCentury | Apr 2, 2001
Tools & Techniques

VEGF: Connecting SNPs with CYPs

The family of cytochrome P450 (CYP) enzymes, which affect drug metabolism, are providing a fertile playground in the field of individualized medicine. Last week researchers published that a particular polymorphism in the gene for the...
Items per page:
1 - 8 of 8