17:47 , Jun 28, 2018 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on 124 genomic loci could help predict the risk of myopia and other ocular refractive errors. Genome-wide association studies (GWAS) in 255,925 individuals identified associations between ocular refractive errors including myopia and...
19:59 , Apr 11, 2017 |  BC Innovations  |  Distillery Techniques

Drug properties; other

TECHNOLOGY: Pharmacokinetics / pharmacodynamics; drug-drug interactions; computational models A computational model for predicting the PK of ATRA could aid the design of ATRA-dosing strategies and identify drug-drug interactions that could help overcome resistance caused by...
07:00 , Sep 22, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Aldehyde dehydrogenase 1 family member A1 (ALDH1A1); cytochrome P450 26A1 (CYP26A1; CP26)

Cancer INDICATION: Colorectal cancer Patient sample and mouse studies suggest enhancing all-trans retinoic acid (ATRA) levels could help treat colorectal cancer. In tumor samples from colorectal cancer patients, levels of ALDH1A1 - which participates in...