BioCentury | Jul 25, 2020
Translation in Brief

New class of cytosine base editors; plus new U.K. vaccine manufacturing facilities, scalable surrogate assay for COVID-19; combating antibiotic resistance and

...Sciences article describing the new C base editors -- which comprise a Cas9 nickase, a cytidine deaminase...
BioCentury | Jul 10, 2020
Tools & Techniques

Precise base editing of mitochondrial DNA

David Liu and colleagues at the Broad Institute and University of Washington have achieved single-base editing of mitochondrial DNA for the first time, overcoming a limitation of CRISPR-based technologies and opening up new avenues for...
BioCentury | Feb 7, 2020
Translation in Brief

Gilead’s remdesivir vs. 2019-nCov in cells; plus Syndax, Syntrix and Max Planck

...APOE) epsilon 4 ARRB2 - Arrestin β 2 Cas9 - CRISPR-associated protein 9 CDA1 - Cytidine deaminase...
...Planck Institute University of Lausanne Syndax Pharmaceuticals Inc. Dana-Farber Cancer Institute Gilead Sciences Inc. Chinese Academy of Sciences CRISPR-associated protein 9 (Cas9) Cytidine deaminase (CDA) Apolipoprotein...
BioCentury | Jan 17, 2020
Translation in Brief

CPSF3 emerges as new synthetic lethality target in AML and sarcoma

...cancer 2 early onset (BRCA2) Breast cancer 1 early onset (BRCA1) Ataxia telangiectasia and Rad3 related (ATR) (FRP1) Cytidine deaminase (CDA) Poly(ADP-ribose...
BioCentury | Oct 15, 2019
Finance

Cyteir synthetic lethality compound prompts Novo to lead $40M investment

...developing a companion diagnostic to identify patients who over-express the DNA damaging enzyme CDA. Between CDA...
...inhibitors, CYT-0851 could have broader applicability across more cancers because of more prevalent expression of CDA...
...NASDAQ:CELG) also participated in the extension. Targets: BRCA - Breast cancer early onset; CDA - Cytidine deaminase...
BioCentury | Sep 12, 2019
Distillery Techniques

Beam co-founder describes base editors with reduced RNA editing

...RNA editing in HEK cells. In comparison to a cytosine base editor that contained the cytidine deaminase...
BioCentury | Jul 1, 2019
Company News

Long wait cost Pfizer until BEACON data clinched Array deal

...restart of talks with Pfizer in December 2018, which progressed to a confidential disclosure agreement (CDA...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Revving up metabolism at ASH 2018

...Anderson Cancer Center, Houston, Texas WindMIL Therapeutics Inc., Baltimore, Md. Targets AICDA (AID) - Activation-induced cytidine deaminase...
BioCentury | Oct 10, 2018
Preclinical News

In utero base editing corrects metabolic birth defect

...the CRISPR-Cas9 (CRISPR-associated protein 9) system that combines a catalytically inactive version of Cas9 with cytidine deaminase...
BioCentury | Apr 13, 2018
Company News

Novo Nordisk licenses sickle cell candidate from EpiDestiny

...EPI01 is an oral formulation of two small molecules -- DNA methyltransferase inhibitor decitabine plus cytidine deaminase (CDA)...
...EpiDestiny Inc., Solon, Ohio Novo Nordisk A/S (CSE:NOVOB; NYSE:NVO), Bagsvaerd, Denmark Business: Hematology Mary Romeo Novo Nordisk A/S Cytidine deaminase (CDA) DNA...
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