00:12 , Oct 10, 2018 |  BC Extra  |  Preclinical News

In utero base editing corrects metabolic birth defect

Researchers from Children's Hospital of Philadelphia and University of Pennsylvania opened the door to prenatal genome editing by using a relatively new CRISPR-based approach called base editor 3 to correct tyrosinemia type I, a rare...
19:18 , Apr 13, 2018 |  BC Week In Review  |  Company News

Novo Nordisk licenses sickle cell candidate from EpiDestiny

EpiDestiny Inc. (Solon, Ohio) granted Novo Nordisk A/S (CSE:NOVOB; NYSE:NVO) exclusive, worldwide rights to EPI01 to treat sickle cell disease (SCD) and beta-thalassemia. EpiDestiny is eligible for more than $400 million, comprising a $12 million...
22:20 , Apr 5, 2018 |  BC Extra  |  Company News

Novo in deal for EpiDestiny's hematology candidate

EpiDestiny Inc. (Solon, Ohio) granted Novo Nordisk A/S (CSE:NOVOB; NYSE:NVO) exclusive, worldwide rights to EPI01 to treat sickle cell disease (SCD) and beta-thalassemia. EpiDestiny is eligible for more than $400 million, comprising a $12 million...
02:10 , Dec 8, 2017 |  BC Innovations  |  Targets & Mechanisms

Epiphenomena at ASH

While it’s no surprise that cell therapy research is dominant in hematology, the emergence of epigenetics as an equally large focus at this year’s ASH meeting is more notable, reinforcing the resurgence of a field...
16:48 , Oct 17, 2017 |  BC Innovations  |  Distillery Therapeutics

Hematology

INDICATION: Thalassemia Cell and human embryo studies suggest base editing of β-globin mutations could help treat β-thalassemia. In fibroblast cells from a β-thalassemia patient harboring an A28G SNP in β-globin, a base editor system comprising...
20:41 , Sep 29, 2017 |  BC Extra  |  Preclinical News

Researchers use base editing to correct beta-thalassemia mutation

In a paper published in...
22:39 , Sep 14, 2017 |  BC Extra  |  Preclinical News

Intratumor bacteria could confer resistance to gemcitabine

In a paper published in...
23:04 , Jun 29, 2017 |  BC Extra  |  Preclinical News

Paper describes inducible CRISPR

In a...
23:03 , Jun 29, 2017 |  BC Extra  |  Preclinical News

Paper describes inducible CRISPR

In a...
18:45 , Jun 29, 2017 |  BC Innovations  |  Translation in Brief

CRISPR to the point

As improvements to CRISPR-based gene editing continue apace, a Harvard University leader in the space has produced an updated version of a technology he described only a year ago for accurately generating point mutations without...