07:00 , Jun 2, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Cystathionine β synthase (CBS)

Endocrine/metabolic disease INDICATION: Metabolic Mouse studies suggest CBS could help treat homocystinuria, in which deficiency of the enzyme can cause accumulation of homocysteine in serum and organs. In a mouse model of homocystinuria with non-lethal...
08:00 , Mar 3, 2014 |  BioCentury  |  Emerging Company Profile

CBS: Sniffing out cancer therapy

CBS Therapeutics Inc. is developing first-in-class inhibitors of cystathionine beta synthase that could synergize with existing therapies to treat both KRAS-mutant and wild-type metastatic colorectal cancer. Cystathionine beta synthase (CBS) is found in many cell...
07:00 , Aug 15, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Colorectal cancer Cystathionine b-synthase (CBS) In vitro and mouse studies suggest inhibiting CBS could help treat colorectal cancer. In a human colon cancer cell line,...
07:00 , Oct 4, 2012 |  BC Innovations  |  Strategy

Buddy system for orphan disease

The Wellcome Trust has launched a program to fund early stage translational research in rare and orphan diseases. Participation in the program, dubbed the Pathfinder Award Scheme, requires academics or not-for-profits to pair up with...
08:00 , Jan 12, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Inflammatory bowel disease (IBD) Cystathionine b-synthase (CBS); cystathionase (CTH) Cell culture studies suggest blocking hydrogen sulfide (H2S) signaling could help treat IBD. Excessive T...
07:00 , Sep 19, 2011 |  BC Week In Review  |  Company News

NovAliX, Fondation Jerome Lejeune deal

NovAliX and the foundation partnered to develop small molecules against cystathionine beta-synthase ( CBS ) to treat Trisomy 21. NovAliX will be responsible for development under the two-year deal, which may be renewed. The genetic...
07:00 , Mar 12, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Genitourinary disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Genitourinary disease Erectile dysfunction (ED) Cystathionine β-synthase (CBS); cystathionase (cystathionine γ-lyase) (CTH) Studies in cell culture and in rats suggest that intracavernous...
08:00 , Nov 6, 2008 |  BC Innovations  |  Targets & Mechanisms

Gassing hypertension

U.S. and Canadian researchers have shown that an endogenous gas, hydrogen sulfide (H 2 S), can function as an endothelial cell-derived relaxing factor that regulates blood pressure. 1 The finding reveals potential new intervention points...
07:00 , Apr 5, 1999 |  BioCentury  |  Finance

The barber's chairman

Ebb & Flow The barber's chairman Meanwhile,...
08:00 , Jan 26, 1998 |  BioCentury  |  Finance

Vivus bowls over NBC

Ebb & Flow NBC's refusal to air...