07:00 , Apr 30, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Cyclin G associated kinase (GAK)

Infectious disease INDICATION: Hepatitis C virus (HCV) In vitro studies suggest isothiazolo[5,4-b]pyridine-based GAK inhibitors could help treat HCV infection. Two lead isothiazolo[5,4-b]pyridine analogs from a small molecule library screen bound GAK's ATP binding site with Kd values...