22:54 , Sep 14, 2017 |  BC Innovations  |  Targets & Mechanisms

Platelets YAP at cancer

While elevated platelet levels often signify an underlying malignancy, the molecular mechanisms linking the two are not well understood. Now, a team from MD Anderson has shown a well-known, but barely exploited signaling pathway mediates...
07:00 , Jul 17, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer B cell lymphoma B cell lymphoma 2 (BCL-2; BCL2); cyclin dependent kinase 4 (CDK4); cyclin dependent kinase inhibitor 2A (CDKN2A; INK4a; ARF; p16INK4a); CDKN2B (INK4B;...
07:00 , Mar 14, 2013 |  BC Innovations  |  Cover Story

Squaring the RNA circle

Two European teams have provided the strongest evidence to date that circular RNAs are widely expressed in human cells and have clear regulatory functions. 1,2 The biomedical relevance of circular RNAs remains largely unexplored, but...
08:00 , Mar 3, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Various

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Various Coronary artery disease (CAD); type 2 diabetes Cyclin dependent kinase inhibitor 2B (CDKN2B; INK4B; MTS2); interferon-a21 (IFNA21); methylthioadenosine phosphorylase (MTAP)...
08:00 , Feb 24, 2011 |  BC Innovations  |  Targets & Mechanisms

Inflaming cardiovascular passions

Ever since a 2007 genomewide association study uncovered a region of chromosome 9 as a major player in determining risk for cardiovascular diseases, researchers have struggled to understand how locus 9p21 actually causes disease. Now,...
07:00 , Jul 16, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer rs1412829; rs6010620 Genomewide association studies identified two loci that could help predict risk of high-grade glioma. In adults with high-grade glioma, the rs1412829...
08:00 , Mar 5, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cardiovascular disease Coronary heart disease (CHD); periodontitis Cyclin-dependent kinase inhibitor 2A (CDKN2A; INK4a; ARF); CDKN2B; SNP rs1333048 A genomewide association study...
00:09 , May 9, 2007 |  BC Extra  |  Clinical News

Allele on chromosome 9 linked to coronary heart disease

Two separate papers published in Science identified the association of a common sequence variant on chromosome 9 with risk for coronary heart disease. Both studies used genome-wide association scanning to identify an allele located near...
07:00 , May 21, 2001 |  BC Week In Review  |  Clinical News

BRCA1 and BRCA2 breast and ovarian cancer genes regulatory update

Myriad Genetics Inc. (MYGN), Salt Lake City, Utah   Product: BRCA1 and BRCA2 breast and ovarian cancer genes   Business: Pharmacogenetics   MYGN received eight patents covering the use of BRCA1 and BRCA2 to develop...
08:00 , Dec 13, 1999 |  BC Week In Review  |  Clinical News

MTS2 regulatory update

MYGN received U.S. Patent No. 5,994,095 covering the MTS2 (p19) gene that regulates the p53 pathway and use of the gene in diagnostic and therapeutic products. Myriad Genetics Inc. (MYGN), Salt Lake City, Utah  ...