22:10 , Jan 31, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Parkinson's disease (PD) Patient samples and mouse studies suggest promoting clearance of CDKN2A-positive senescent cells could help treat PD. In postmortem substantia nigra tissue samples from patients, levels of the cellular senescence cell marker CDKN2A...
17:07 , Sep 13, 2017 |  BC Innovations  |  Distillery Therapeutics

Musculoskeletal

INDICATION: Osteoporosis Mouse studies suggest inhibiting senescent cells could help treat age-related bone loss. In aged, transgenic mice expressing the senescence marker human CDKN2A, a tool compound that depletes CDKN2A-positive cells decreased the number of senescent...
22:38 , Jul 20, 2017 |  BC Innovations  |  Finance

Sharpless edge for NCI

The National Cancer Institute is poised to enter a new phase, under the leadership of Norman (Ned) Sharpless, following the June 9 announcement by the White House of the president’s choice to fill the large...
14:16 , May 16, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer In vitro and cell culture studies identified a quinolone-quinazoline conjugate-based DNMT3A inhibitor that could help treat colorectal cancer. Chemical synthesis and testing of quinolone-quinazoline conjugate analogs in vitro yielded a compound that inhibited...
18:11 , May 3, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Cell models; animal models A human pancreatic intraepithelial neoplastic cell line and mice implanted with the cells could be used to identify markers and screen therapies for early stage pancreatic ductal adenocarcinoma (PDAC). The model...
12:56 , Mar 15, 2017 |  BC Innovations  |  Distillery Therapeutics

Pulmonary

INDICATION: Pulmonary fibrosis Patient sample and mouse studies suggest promoting senescent cell clearance could help treat idiopathic pulmonary fibrosis (IPF). In lung samples from patients, levels of the cellular senescence marker CDKN2A were higher than in...
07:00 , Oct 31, 2016 |  BioCentury  |  Tools & Techniques

Slaying senescent cells

  With a whopper of a B round and a new publication demonstrating both a causal role of senescent cells in atherosclerosis, and a therapeutic effect of eliminating them, Unity Biotechnology Inc. is readying to push...
07:00 , Apr 7, 2016 |  BC Innovations  |  Distillery Techniques

DISEASE MODELS

Disease models TECHNOLOGY: Transgenics and knockouts A multiplexed CRISPR/Cas9 mouse model of orthotopic pancreatic cancer could be useful for screening therapies to treat the disease. Mice simultaneously transfected with CRISPR/Cas9 vectors expressing guide RNAs that introduced mutations...
07:00 , Mar 24, 2016 |  BC Innovations  |  Translation in Brief

A beta test for senescence

While senescence is usually associated with the down-side of aging, a group at the Hebrew University of Jerusalem has found the process can be beneficial for secretion of insulin by pancreatic β cells, and suggests...
07:00 , Oct 19, 2015 |  BC Week In Review  |  Company News

Oxford Gene sales and marketing update

Oxford launched in Europe the Cytocell Aquarius P16/3c/7c/17c Probe Kit to detect bladder cancer. The fluorescence in situ hybridization (FISH) test, which has CE Mark approval, detects aneuploidies in chromosomes 3, 7 and 17...