17:38 , Sep 26, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neurology Mouse models suggest clearing senescent cells could help treat tau-mediated neurodegenerative diseases. In a mouse model of tauopathy expressing mutant human tau in neurons, systemic expression of a fusion human transgene based on the...
01:21 , Sep 21, 2018 |  BC Innovations  |  Tools & Techniques

Precision for pancreatic cancer

Real-time sequencing and organoid-based screens in pancreatic cancer could place new targets and biomarkers in the hands of drug developers looking for ways to side-step KRAS, a gene mutated in 90% of patients. Because KRAS...
18:42 , Sep 19, 2018 |  BC Extra  |  Preclinical News

Mayo Clinic team implicates senescent cells in neurodegenerative diseases

Clearing out senescent brain cells could prevent tau-mediated neurodegeneration and cognitive loss, although it's still too early to determine whether the approach can halt or reverse disease progression, according to a Nature letter from Mayo...
22:10 , Jan 31, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Parkinson's disease (PD) Patient samples and mouse studies suggest promoting clearance of CDKN2A-positive senescent cells could help treat PD. In postmortem substantia nigra tissue samples from patients, levels of the cellular senescence cell marker CDKN2A...
17:07 , Sep 13, 2017 |  BC Innovations  |  Distillery Therapeutics

Musculoskeletal

INDICATION: Osteoporosis Mouse studies suggest inhibiting senescent cells could help treat age-related bone loss. In aged, transgenic mice expressing the senescence marker human CDKN2A, a tool compound that depletes CDKN2A-positive cells decreased the number of senescent...
22:38 , Jul 20, 2017 |  BC Innovations  |  Finance

Sharpless edge for NCI

The National Cancer Institute is poised to enter a new phase, under the leadership of Norman (Ned) Sharpless, following the June 9 announcement by the White House of the president’s choice to fill the large...
14:16 , May 16, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer In vitro and cell culture studies identified a quinolone-quinazoline conjugate-based DNMT3A inhibitor that could help treat colorectal cancer. Chemical synthesis and testing of quinolone-quinazoline conjugate analogs in vitro yielded a compound that inhibited...
18:11 , May 3, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Cell models; animal models A human pancreatic intraepithelial neoplastic cell line and mice implanted with the cells could be used to identify markers and screen therapies for early stage pancreatic ductal adenocarcinoma (PDAC). The model...
12:56 , Mar 15, 2017 |  BC Innovations  |  Distillery Therapeutics

Pulmonary

INDICATION: Pulmonary fibrosis Patient sample and mouse studies suggest promoting senescent cell clearance could help treat idiopathic pulmonary fibrosis (IPF). In lung samples from patients, levels of the cellular senescence marker CDKN2A were higher than in...
07:00 , Oct 31, 2016 |  BioCentury  |  Tools & Techniques

Slaying senescent cells

  With a whopper of a B round and a new publication demonstrating both a causal role of senescent cells in atherosclerosis, and a therapeutic effect of eliminating them, Unity Biotechnology Inc. is readying to push...