00:28 , Aug 15, 2019 |  BC Innovations  |  Distillery Therapeutics

Three host gene targets for malaria

DISEASE CATEGORY: Infectious INDICATION: Malaria A team from Duke University identified host targets whose inhibition could prevent malaria infection. A human liver-cell based RNAi screen of 6,951 druggable genes identified 14 that promoted the liver...
01:07 , Jan 8, 2019 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Anxiety Mouse studies suggest depleting senescent cells could help treat obesity-induced anxiety. In a transgenic mouse model of obesity expressing the senescence marker human CDKN2A, a tool compound that depletes CDKN2A-positive cells decreased anxiety-like...
17:38 , Sep 26, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neurology Mouse models suggest clearing senescent cells could help treat tau-mediated neurodegenerative diseases. In a mouse model of tauopathy expressing mutant human tau in neurons, systemic expression of a fusion human transgene based on...
01:21 , Sep 21, 2018 |  BC Innovations  |  Tools & Techniques

Precision for pancreatic cancer

Real-time sequencing and organoid-based screens in pancreatic cancer could place new targets and biomarkers in the hands of drug developers looking for ways to side-step KRAS, a gene mutated in 90% of patients. Because KRAS...
18:42 , Sep 19, 2018 |  BC Extra  |  Preclinical News

Mayo Clinic team implicates senescent cells in neurodegenerative diseases

Clearing out senescent brain cells could prevent tau-mediated neurodegeneration and cognitive loss, although it's still too early to determine whether the approach can halt or reverse disease progression, according to a Nature letter from Mayo...
22:10 , Jan 31, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Parkinson's disease (PD) Patient samples and mouse studies suggest promoting clearance of CDKN2A-positive senescent cells could help treat PD. In postmortem substantia nigra tissue samples from patients, levels of the cellular senescence cell marker...
17:07 , Sep 13, 2017 |  BC Innovations  |  Distillery Therapeutics

Musculoskeletal

INDICATION: Osteoporosis Mouse studies suggest inhibiting senescent cells could help treat age-related bone loss. In aged, transgenic mice expressing the senescence marker human CDKN2A , a tool compound that depletes CDKN2A-positive cells decreased the number...
22:38 , Jul 20, 2017 |  BC Innovations  |  Finance

Sharpless edge for NCI

The National Cancer Institute is poised to enter a new phase, under the leadership of Norman (Ned) Sharpless, following the June 9 announcement by the White House of the president’s choice to fill the large...
14:16 , May 16, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer In vitro and cell culture studies identified a quinolone-quinazoline conjugate-based DNMT3A inhibitor that could help treat colorectal cancer. Chemical synthesis and testing of quinolone-quinazoline conjugate analogs in vitro yielded a compound that...
18:11 , May 3, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Cell models; animal models A human pancreatic intraepithelial neoplastic cell line and mice implanted with the cells could be used to identify markers and screen therapies for early stage pancreatic ductal adenocarcinoma (PDAC). The...