19:29 , Aug 8, 2019 |  BC Innovations  |  Distillery Therapeutics

CDK7 inhibition for drug-resistant cancers

DISEASE CATEGORY: Cancer INDICATION: Brain cancer; sarcoma; solid tumors Inhibiting CDK7 could treat hedgehog signaling-driven cancers resistant to SMO inhibitors. A CDK7 inhibitor tool compound decreased viability of cells resistant to SMO inhibitors and driven...
13:09 , Dec 4, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Ovarian cancer Cell culture and mouse studies identified a CDK7/CDK12/CDK13 inhibitor that could help treat ovarian cancer. Screening of 42 small molecules targeting transcriptional and/or epigenetic components in two human ovarian cancer cell lines...
04:50 , Nov 30, 2018 |  BC Innovations  |  Targets & Mechanisms

Revving up metabolism at ASH 2018

Cancer metabolism is a prominent theme at this year’s ASH meeting, with researchers broadening the tent from metabolic targets that drive hematologic malignancies to those that intersect with other hot topics, notably immuno-oncology and epigenetics....
23:37 , Dec 21, 2017 |  BC Extra  |  Preclinical News

New pathway could overcome resistance to TKIs in cancer

In a paper published in Cancer Research , researchers at Dana-Farber Cancer Institute and colleagues discovered that the recently identified ufmylation pathway plays a role in resistance to tyrosine kinase inhibitors (TKIs), and suggested that...
21:27 , Oct 26, 2017 |  BC Innovations  |  Tools & Techniques

Ripe for enhancement

Although still largely the purview of academics, technologies for mapping enhancers to the genes they control are rapidly gaining efficiency and promise to unlock a trove of new targets for drug developers. But companies will...
20:46 , Oct 10, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Nasopharyngeal cancer Cell culture and mouse studies identified inhibitors of CDK7 that could help treat nasopharyngeal cancer (NPC). A screen of 126 small molecules identified three known inhibitors CDK7 that inhibited proliferation of seven...
03:01 , May 6, 2017 |  BioCentury  |  Product Development

Finding gems in India

For Agios Pharmaceuticals Inc. , the decision to license molecules from Indian CRO Aurigene Discovery Technologies Ltd. was a special case intended to save time getting a new project off the ground, rather than part...
18:14 , May 3, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Brain cancer Cell culture and mouse studies suggest inhibiting BRD4 or CDK7 could help treat diffuse intrinsic pontine glioma (DIPG). In DIPG cells from eight patients, a bromodomain inhibitor tool compound or a CDK7...
15:59 , Apr 25, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Ovarian cancer Cell culture studies suggest inhibiting CDK7 could help treat ovarian cancer. In five human ovarian cancer cell lines, a CDK7 inhibitor tool compound decreased proliferation compared with vehicle. In three of the...
07:00 , Aug 18, 2016 |  BC Innovations  |  Translation in Brief

The CDK5 checkpoint

Despite the clinical success of checkpoint inhibitors, immuno-oncologists still have an incomplete understanding of how the receptors and their ligands prevent antitumor immunity. In a new study, Case Western Reserve University researchers found mechanistic data...