BioCentury | Aug 26, 2020
Finance

Expanded management team, precision cancer therapies draw crossovers to Kinnate’s $98M series C

...to existing therapies. In addition, Kinnate plans to use the money to further develop a CDK12...
BioCentury | Jun 26, 2020
Distillery Therapeutics

CDK12 identified as myotonic dystrophy target

...DISEASE CATEGORY: Musculoskeletal INDICATION: Myotonic dystrophy type 1 (DM1) Inhibiting the transcription elongation regulator CDK12 could...
...CTG repeat expansions in the DMPK gene that result in cellular accumulation of mutant RNA. CDK12...
...LSE:GSK; NYSE:GSK) has the CDK12 inhibitor GSK3186899 in Phase I testing for visceral leishmaniasis. TARGET/MARKER/PATHWAY: Cyclin dependent kinase 12 (CDK12)...
BioCentury | Dec 12, 2019

Combined inhibition of CDK12 and CDK13 for TNBC

...Breast cancer A Moffitt Cancer Center and Research Institute team showed that dual inhibition of CDK12...
...cancer (TNBC). In four human TNBC cell lines, an optimized heteroaromatic purine based on a CDK12...
...it in Phase I through Phase III testing for a variety of solid cancers. TARGET/MARKER/PATHWAY: Cyclin dependent kinase 12 (CDK12)...
BioCentury | Jun 7, 2019
Targets & Mechanisms

Following PARP, ATR axis next in line to expand synthetic lethal drug class

...genes, or in a gene network known as the Fanconi anemia/BRCA pathway, which includes ATR, CDK12...
...onset Chk1 (CHEK1) - Checkpoint kinase 1 Chk2 (CHEK2) - Checkpoint kinase 2 CDK12 - Cyclin dependent kinase 12...
BioCentury | Dec 4, 2018
Distillery Therapeutics

Cancer

...INDICATION: Ovarian cancer Cell culture and mouse studies identified a CDK7/CDK12/CDK13 inhibitor that could help treat...
...molecules targeting transcriptional and/or epigenetic components in two human ovarian cancer cell lines identified a CDK7/CDK12/CDK13...
...and 0.2 μM. Also in the cell lines, the combination of a CDK7 inhibitor and CDK12/CDK13...
BioCentury | Aug 16, 2018
Distillery Therapeutics

Cancer

...INDICATION: Breast cancer In vitro and cell culture studies identified a dual CDK12/CDK13 inhibitor that could...
...enzyme activity assays followed by structure-based optimization of hits yielded an arylurea analog that inhibited CDK12...
...nM, respectively. In a human breast cancer cell line-based enzyme activity assay, the compound inhibited CDK12...
BioCentury | May 9, 2018
Distillery Therapeutics

Cancer

...proliferation compared with chemotherapy alone. In one of the cell lines, siRNA targeting CDK1 or CDK12...
...plus cisplatin increased apoptosis compared with cisplatin alone, and in both cell lines, the dual CDK1/CDK12...
...early onset (BRCA1); BRCA1 associated RING domain 1 (BARD1); cyclin dependent kinase 1 (CDK1; CDC2); CDK12...
BioCentury | Dec 21, 2017
Preclinical News

New pathway could overcome resistance to TKIs in cancer

...and CDK12. Jennie Walters erlotinib Tarceva Astellas Pharma Inc. Broad Institute of MIT and Harvard Dana-Farber Cancer Institute Harvard CREB binding protein (CREBBP) (CBP) Cyclin dependent kinase 12 (CDK12) Cyclin...
BioCentury | Apr 14, 2016
Product R&D

AACR by the numbers

...Andel Institute 1565 Cyclin-dependent kinase 13 (CDK13) Sarcoma Studies in cancer cell lines suggest inhibiting CDK12...
BioCentury | Jul 24, 2014
Targets & Mechanisms

Selecting CDK7

...improved by addressing this cysteine. Therefore, it is an important result that the affinity of CDK12...
Items per page:
1 - 10 of 11