21:14 , Jun 8, 2017 |  BC Extra  |  Clinical News

Cyclin D3-CDK6 levels predict tumor response to CDK4/6 inhibitors

In an article published online in Nature on Wednesday, scientists reported that high levels of tumor cyclin D3-cyclin-dependent kinase 6 ( CDK6 ) correlated with long-term tumor regression after blockade of CDK4 and CDK6. Inhibitors...
08:00 , Feb 26, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/ marker/ pathway Summary Licensing status Publication and contact information Cancer Cancer Cyclin-dependent kinase 4 (CDK4); cyclin D3 (CCND3) Structural determination of the CDK4-CCND3 complex could be useful for identifying...
07:00 , Jun 19, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Cancer Acute myelogenous leukemia (AML); leukemia; multiple myeloma (MM) Cyclin D1 (CCND1; BCL1); cyclin D2 (CCND2); cyclin D3 (CCND3) Studies in...
07:00 , May 8, 2008 |  BC Innovations  |  Targets & Mechanisms

D-coupling Multiple Myeloma's Codependents

Three years ago researchers at the Mayo Clinic Arizona reported that most types of multiple myeloma overexpress cyclin D1 and/or cyclin D2. 1 Following on that earlier work, a new research team at the clinic...
07:00 , Aug 17, 1998 |  BC Week In Review  |  Company News

Alfacell other research news

ACEL described in Leukemia a mechanism by which Onconase may regulate cancer cell growth. Human lymphoma cells treated with Onconase arrested in the G1 phase of the cell cycle, resulting in reduced proliferation and apoptosis...