07:00 , Oct 22, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Cyclin dependent kinase 8 (CDK8); cyclin C (CCNC)

Cancer INDICATION: Leukemia In vitro, cell culture and mouse studies identified cortistatin A as an inhibitor of the CDK8-CCNC interaction that could help treat leukemia. In vitro, cortistatin A bound the CDK8-CCNC complex with a Kd of...
07:00 , Sep 25, 2008 |  BC Innovations  |  Targets & Mechanisms

CDK8 is Enough in Colorectal Cancer

Of the 11 known cyclin-dependent kinases, about half have long been the focus of cancer drug developers because they are involved in controlling cell-cycle progression, which goes into overdrive in cancer. However, none of the...