BioCentury | Aug 28, 2020
Emerging Company Profile

Concarlo: targeting proliferation and resistance in one go

...4CDK6 – cyclin dependent kinase 6p27 (Kip1; CDKN1B...
...– protein tyrosine kinase 6 Virginia Li Cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) Cancer Breast...
BioCentury | Jul 25, 2020
Translation in Brief

New class of cytosine base editors; plus new U.K. vaccine manufacturing facilities, scalable surrogate assay for COVID-19; combating antibiotic resistance and

...a peptide that could overcome breast cancer resistance to CDK4/6 inhibitors. The peptide targets the CDKN1B...
...4 CDK6 - Cyclin dependent kinase 6 DRD3 - Dopamine D3 receptor CDKN1B (p27, Kip1) - Cyclin-dependent kinase inhibitor 1B...
BioCentury | Jul 16, 2020
Emerging Company Profile

Fountain Therapeutics: an AI-based platform to reverse cellular aging

Fountain is using an unbiased data-driven approach to identify compounds that reverse the biological process of aging, and in contrast to the traditional disease hypothesis-driven approach, the company is agnostic to indication. “Eighty percent of...
BioCentury | Feb 22, 2020
Product Development

Regenerative medicine for hearing loss makes quiet progress

...HDAC - Histone deacetylase HES1 - Hairy and enhancer of split1 p27 (Kip1; CDKN1B) - Cyclin-dependent kinase inhibitor 1B Selina...
BioCentury | Jan 8, 2019
Distillery Therapeutics


INDICATION: Anxiety Mouse studies suggest depleting senescent cells could help treat obesity-induced anxiety. In a transgenic mouse model of obesity expressing the senescence marker human CDKN2A, a tool compound that depletes CDKN2A-positive cells decreased anxiety-like...
BioCentury | Sep 26, 2018
Distillery Therapeutics


INDICATION: Neurology Mouse models suggest clearing senescent cells could help treat tau-mediated neurodegenerative diseases. In a mouse model of tauopathy expressing mutant human tau in neurons, systemic expression of a fusion human transgene based on...
BioCentury | Sep 21, 2018
Tools & Techniques

Precision for pancreatic cancer

Real-time sequencing and organoid-based screens in pancreatic cancer could place new targets and biomarkers in the hands of drug developers looking for ways to side-step KRAS, a gene mutated in 90% of patients. Because KRAS...
BioCentury | Sep 19, 2018
Preclinical News

Mayo Clinic team implicates senescent cells in neurodegenerative diseases

Clearing out senescent brain cells could prevent tau-mediated neurodegeneration and cognitive loss, although it's still too early to determine whether the approach can halt or reverse disease progression, according to a Nature letter from Mayo...
BioCentury | Jan 31, 2018
Distillery Therapeutics


INDICATION: Parkinson's disease (PD) Patient samples and mouse studies suggest promoting clearance of CDKN2A-positive senescent cells could help treat PD. In postmortem substantia nigra tissue samples from patients, levels of the cellular senescence cell marker...
BioCentury | Dec 19, 2017
Distillery Therapeutics


INDICATION: Organ damage Mouse studies suggest inhibiting CDKN1A could help treat cardiac injury. In cardiac tissue from a neonatal mouse model of surgical resection-induced cardiac injury, levels of CDKN1A were lower in the regenerating myocardium...
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