17:21 , Aug 30, 2018 |  BC Innovations  |  Tools & Techniques

Master of autism

The discovery of a master regulator of autism risk genes has yielded the first mouse model of the form of the condition that accounts for about 90% of patients, and could spark a new way...
19:19 , Feb 21, 2018 |  BC Innovations  |  Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds A peptidomimetic compound that inhibits the DCUND1-UBE2M interaction and neddylation of cullin 3 (CUL3) could be used to probe the role of the CUL3/DCN1 cullin-RING ligase complex in squamous cell lung carcinoma....
07:00 , Aug 18, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Cullin 3 (CUL3)

Cancer INDICATION: Brain cancer Cell culture, patient sample and mouse studies suggest promoting CUL3 expression could help treat glioblastoma multiforme (GBM). In patient samples, tumor levels of CUL3 were lower than levels in matched samples...
08:00 , Feb 2, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Renal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Renal disease Renal disease Kelch-like 3 (KLHL3); cullin 3 (CUL3); solute carrier family 12 potassium-chloride transporter member 3 (SLC12A3; NCCT) Genomic analysis suggests mutations in KLHL3...
08:00 , Feb 2, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bladder cancer Keratin 14 (KRT14) Patient sample studies suggest KRT14 could help predict bladder cancer prognosis. In two sets of gene and protein expression data...