19:24 , Feb 8, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Nerve damage Mouse studies suggest CRYAB could help treat peripheral nerve damage. In a mouse model of sciatic nerve damage, human CRYAB increased remyelination of the sciatic nerve and mechanical sensitivity and decreased gait defects...
08:00 , Nov 12, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Crystallin α B (CRYAB; HSPB5)

Ophthalmic disease In vitro, mouse and patient sample studies suggest a chaperone of CRYAB could help treat cataract. A differential scanning fluorometry-based screen on a small molecule library identified a lead compound that decreased formation of...
08:00 , Nov 12, 2015 |  BC Innovations  |  Product R&D

Crystallin-clear ViewPoint

By exploring the biophysics of proteins with disease-associated mutations, a UCSF group has developed a way to screen for drugs that rescue the activity of non-enzymatic targets, and proved its value with molecular chaperones. After...
08:00 , Jan 17, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) Dopamine D2 receptor In vitro and mouse studies suggest dopamine D2 receptor agonists...
07:00 , Aug 16, 2012 |  BC Innovations  |  Targets & Mechanisms

Amyloids for inflammation

Researchers at Stanford University have found that systemic treatment with b-amyloid peptides can reduce inflammation and reverse paralysis in mouse models of multiple sclerosis.1Cardinal Therapeutics Inc. has licensed the work and now is developing anti-inflammatory...
08:00 , Mar 1, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammation Crystallin aB (CRYAB; HSPB5) In vitro studies identified a mechanism for HSPB5's anti-inflammatory activity that...
07:00 , Jul 3, 1995 |  BC Week In Review  |  Company News

Netherlands Institute for Brain Research other research news

Researchers have identified a key antigenic molecule in the immune attack on the nervous system that causes multiple sclerosis. As reported in Nature, the scientists tested the responses of primed human T cells against...