BioCentury | May 8, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: April 2019

...and Cryptosporidium lysine-tRNA ligase that could help treat malaria and Cryptosporidium infections University of Dundee Distillery Therapeutics Cryptosporidium lysine-tRNA ligase...
BioCentury | Apr 2, 2019
Distillery Therapeutics

Microbial lysine-tRNA ligase inhibitor for malaria and Cryptosporidium

...culture and mouse studies identified a chromene carboxamide-based inhibitor of P. falciparum lysine-tRNA ligase and Cryptosporidium lysine-tRNA ligase...
...optimization the compound's potency and selectivity. TARGET/MARKER/PATHWAY: Plasmodium falciparum lysine-tRNA ligase (P. falciparum lysine-tRNA ligase); Cryptosporidium lysine-tRNA ligase...
...2019 doi:10.1073/pnas.1814685116 CONTACT: Ian H. Gilbert, University of Dundee, Dundee, U.K. email: i.h.gilbert@dundee.ac.uk Claire Quang University of Dundee Cryptosporidium lysine-tRNA ligase Plasmodium...
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