BioCentury | Jun 6, 2020
Translation in Brief

Engineered bacteria for targeted bacterial killing; plus Cas12a base editors, base editing to restore hearing and more

Targeted delivery of antibacterial toxins  University of Washington researchers have co-opted a bacterial secretion system to enable killing of select bacterial species. They d escribed in Cell Host & Microbe how they programmed bacteria with...
BioCentury | May 23, 2020
Translation in Brief

A three-compound dengue treatment; plus reversing antibiotic resistance, AbCellera-Lilly, reducing cholesterol with CRISPR and COVID cash for Sherlock

Hindering dengue by combining host- and virus-targeted drugs  In a Cell Chemical Biology article , Stanford University scientists combined two host-targeted compounds with a virus-targeted compound to yield potent dengue treatment. A DHODH inhibitor tool compound,...
BioCentury | May 20, 2020

Mammoth, GSK to take CRISPR diagnostics beyond the centralized lab

Mammoth’s new partnership with GSK builds on the momentum CRISPR-based diagnostics are generating during the COVID-19 pandemic and applies the technology where its benefits will be most apparent: the point-of-care and at-home settings. The companies...
BC Extra | Dec 11, 2019
Tools & Techniques

Editas shows better gene editing using Cas9 alternative for sickle cell, thalassemia

Editas is using an alternative to Cas9 to develop a differentiated sickle cell and β thalassemia CRISPR gene therapy. Preclinical data presented Monday at ASH suggest that ex vivo gene editing could be more effective...
BC Innovations | Aug 29, 2019
Distillery Techniques

CRISPR responsive hydrogel for drug release

TECHNIQUES CATEGORY: Drug Delivery TECHNOLOGY: Polymers An MIT and and Wyss Institute team led by Sherlock Biosciences Inc. co-founder James Collins engineered hydrogels that use CRISPR-based DNA cleavage as a switch to release compounds. The...
BC Extra | Aug 23, 2019
Preclinical News

Aug. 23 Preclinical Quick Takes: Mission Bio launches new feature in single-cell analysis platform; plus CRISPR-triggered hydrogel cargo release and more

Mission Bio expands single-cell analysis platform Mission Bio Inc. (South San Francisco, Calif.) launched Copy Number Analysis, a new feature integrated into its Tapestri Platform, to enable simultaneous measurement of copy number variants along with...
BC Innovations | Aug 22, 2019
Distillery Techniques

CRISPR-based system for multiplexed gene regulation

TECHNIQUES CATEGORY: Drug platforms TECHNOLOGY: Gene therapy ETH Zurich researchers reported a single-plasmid CRISPR system that could be used for multiplexed gene regulation or editing. Each plasmid encoded an Acidaminococcus Cas12a nuclease fused to transcriptional...
BC Extra | Aug 15, 2019
Preclinical News

Aug. 15 Preclinical Quick Takes: Implicating the tumor microbiome in cancer; plus computational pain classification, multiplexed CRISPR and LUCA

MD Anderson links microbiome to pancreatic cancer  University of Texas MD Anderson Cancer Center researchers suggested the tumor microbiome can predict survival in pancreatic ductal adenocarcinoma (PDAC) patients and gut microbiome transfer can alter tumor...
BioCentury | Jun 14, 2019
Emerging Company Profile

Sherlock: Leveraging CRISPR, synthetic biology for diagnostics

By taking advantage of two hot technologies, Sherlock is developing a pair of molecular diagnostics that can be used alone or together to rapidly and accurately detect disease in a wide variety of applications. Sherlock...
BC Innovations | May 23, 2019
Translation in Brief

Template-free CRISPR for correcting pathogenic duplications

A UMass med school team has shown how template-free CRISPR could repair pathogenic DNA duplications and identified over a hundred disease-associated mutations as targets for the new method. Author Scot Wolfe, a professor of molecular,...
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