BioCentury | Oct 4, 2018
Distillery Techniques

Assays and screens; biomarkers

...NFKBIA (nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor α), creatine kinase brain (CKB...
...Wash. email: coletrap@uw.edu CONTACT: Jay Shendure, same affiliation as above email: shendure@uw.edu Sandi Wong University of Washington Creatine kinase brain (CKB) Nuclear...
BioCentury | Feb 19, 2015
Distillery Therapeutics

Therapeutics: Creatine kinase brain (CKB); microRNA-483-5p (miR-483-5p); microRNA-551a (miR-551a)

...Cancer INDICATION: Colorectal cancer Mouse studies suggest upregulating miR-483-5p and miR-551a or inhibiting CKB could help...
...mouse xenograft models of metastatic colon cancer, the CKB inhibitor cyclocreatine or shRNA knockdown of CKB...
...an energy source, in preclinical development for colorectal cancer and undisclosed solid tumors. TARGET/MARKER/PATHWAY: Creatine kinase brain (CKB...
BioCentury | Sep 11, 2008
Distillery Therapeutics

This Week in Therapeutics

...suggest that inhibiting CKB may be useful for treating osteoporosis. Small hairpin RNA knockdown of CKB...
...that seen for osteoclasts treated with empty vector (p<0.01). In a mouse model of osteoporosis, Ckb...
...inhibitor, showed less bone loss than untreated controls. Next steps include evaluating other small molecule CKB...
BioCentury | Feb 7, 2000
Company News

Human Genome Sciences other research news

HGSI researchers and colleagues published in the Journal of Immunology the identification of Met-CkB7 (also known as the beta chemokine MIP-4) as an inhibitor of the CCR3 receptor on eosinophils, which are immune cells involved...
BioCentury | Jan 31, 2000
Clinical News

HGSI discovers asthma/allergy protein

Human Genome Sciences (HGSI) and colleagues reported the discovery of met-chemokine beta seven (Met-CkB7), a protein that HGSI said blocks a receptor on eosinophils, which induce asthma and allergy symptoms. The discovery was published in...
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