19:12 , Mar 7, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Coronavirus In vitro and cell culture studies identified a peptide inhibitor of coronavirus S protein that could help treat Middle East respiratory syndrome (MERS) coronavirus infection. Chemical synthesis and testing in HEK cell-based viral...
19:22 , Sep 19, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Coronavirus Cell culture studies suggest an engineered variant of Middle East respiratory syndrome (MERS) coronavirus S protein that could be used in MERS coronavirus (MERS-CoV) vaccines. The engineered variant contained an ectodomain harboring a...
19:34 , Dec 6, 2016 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockouts A mouse model of MERS-CoV infection could be used to screen therapies and vaccines against the virus. The model was engineered in two steps: CRISPR-mediated editing of dipeptidyl peptidase-4 ( DPP-4...
07:00 , Mar 31, 2016 |  BC Innovations  |  Translation in Brief

Cattle call

Collaborative work between military, industry, university and NIH scientists suggests cattle might help battle emerging infectious diseases. The researchers have developed a line of transgenic cows capable of producing polyclonal human antibodies, and believe the...
08:00 , Mar 10, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Coronavirus S protein

Infectious disease INDICATION: Coronavirus Cell culture and mouse studies suggest polyclonal antibodies against coronavirus S protein could help prevent or treat Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Transgenic cows expressing human IgG were repeatedly...
07:00 , Sep 3, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Coronavirus S protein

Infectious disease INDICATION: Coronavirus Animal studies suggest a DNA vaccine encoding a chimeric coronavirus S protein could help prevent Middle East respiratory syndrome coronavirus (MERS-CoV) infection. The chimeric coronavirus S protein was constructed from consensus...
07:00 , Aug 20, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Coronavirus S protein

Infectious disease INDICATION: Coronavirus Animal studies suggest sequential immunization with DNA vaccine and a subunit of coronavirus S protein could help prevent Middle East respiratory syndrome coronavirus (MERS-CoV) infection. In mice, two intramuscular injections of...
07:00 , Aug 6, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Coronavirus S protein

Infectious disease INDICATION: Coronavirus Studies in cell lines and mice identified two mAbs that could help prevent or treat Middle East respiratory syndrome coronaviral (MERS-CoV) infection. Screening of antibodies from the spleens of chimeric mice...