BC Innovations | Oct 18, 2018
Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Porphyria In vitro , cell culture and mouse studies suggest ciclopirox could help treat congenital erythropoietic porphyria (CEP), which is caused by destabilizing mutations in UROS. Fragment-based screening, structural comparison of the top screening hits...
BC Innovations | Mar 31, 2016
Distillery Techniques

Drug properties

TECHNOLOGY: Drug-drug interactions Plasma and urine levels of coproporphyrin I and coproporphyrin III could help detect drug-drug interactions involving SLCO1B1 and SLCO1B3 . In a human cell line, overexpression of human SLCO1B1 or SLCO1B3 increased uptake...
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