BioCentury | Jul 12, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: June 2018

New Therapeutic Targets and Biomarkers: June 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during June 2018. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Jun 28, 2018
Distillery Therapeutics

Infectious disease

INDICATION: Meningitis Cell culture, mouse and rat studies suggest inhibiting CNTNAP1-dependent bacterial invasion could help treat meningitis caused by E. coli infection. In an E. coli invasion assay in a human brain microvascular endothelial cell...
BioCentury | Aug 13, 2012
Company News

Sigma-Aldrich, Autism Speaks deal

...autism-associated genes. Under the expansion, the partners will generate rat knockout models with the contactin associated protein-like 2 (CNTNAP2...
BioCentury | Oct 20, 2011
Distillery Techniques

Technology: Disease models

...status Publication and contact information Disease models Mouse model for autism spectrum disorder (ASD) Cntnap2 (contactin associated protein-like 2...
BioCentury | Oct 20, 2011
Tools & Techniques

Mouse models of autism

...a CNTNAP2 In the third study, a UCLA team generated mice lacking the ASD-related gene contactin associated protein-like 2...
...In the third study, a UCLA team generated mice lacking the ASD-related gene contactin associated protein-like 2 ( CNTNAP2...
...syndrome of epilepsy, intellectual disability and autism. In 2008, genomewide association studies linked variations in CNTNAP2...
BioCentury | Nov 1, 2010
Tools & Techniques

Arrayed Against Early Autism

...tests will report ambiguous data to patients and pediatricians. He cited the example of contactin associated protein-like 2 (CNTNAP2...
...disorder gene. "We know for sure if you have a truncation in both alleles of CNTNAP2...
BioCentury | Jun 24, 2010
Targets & Mechanisms

Common ground in autism and epilepsy

...affected by CNVs described in Mefford's study, neurexin 1 ( NRXN1 ) and contactin associated protein-like 2 ( CNTNAP2...
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