BioCentury | Jun 11, 2020
Product Development

J&J picks up pace for Warp Speed COVID-19 vaccine

...COVID-19 therapies include clinical data for AZ’s Btk inhibitor Calquence acalabrutinib and trial starts for anti-CTGF...
...is assessing time to and time on ventilation in patients treated with the mAb against CTGF...
...recovering from COVID-19. Targets Btk - Bruton’s tyrosine kinase CRP - C-reactive protein CTGF - Connective tissue growth factor...
BioCentury | May 1, 2020
Product Development

April 30 Quick Takes: Pfizer to co-develop Valneva’s Lyme disease vaccine; plus Aravive-WuXi Biologics, Siga-BARDA, Pear, Capricor

...will use the WuXiBody platform of WuXi Biologics Inc. (HKSE:2269) to develop bispecific antibodies targeting CTGF...
...planning a randomized, placebo-controlled trial. Targets AXL (UFO) - AXL receptor tyrosine kinase CTGF - Connective tissue growth factor...
...oral Arestvyr, SIGA-246) reSET reSET-O CAP-1002 Valneva SE Pfizer Inc. Aravive Inc. WuXi Biologics Inc. Siga Technologies Inc. Capricor Therapeutics Inc. Pear Therapeutics Inc. Interferon (IFN) alpha Connective tissue growth factor (CTGF) COVID-19 ILC...
BioCentury | Jan 25, 2020
Emerging Company Profile

Aluda: targeting the fundamentals

...III candidates GLPG1690, an ENPP2 inhibitor from Galapagos N.V. (Euronext:GLPG; NASDAQ:GLPG); and pamrevlumab (FG-3019), an anti-CTGF...
...Patents: 2 issued covering methods and compositions for anti-vimentin and STAT3 programs Targets CTGF - Connective tissue growth factor (CTGF)...
BioCentury | Aug 26, 2019
Company News

FibroGen’s Neff passes away

...prolyl hydroxylase (HIF-PH) inhibitor that is approved in China, and pamrevlumab, a human mAb against connective tissue growth factor...
BioCentury | Jun 28, 2019
Clinical News

June 28 Clinical Quick Takes: Imfinzi extends survival in Phase III SCLC study; plus LSK, Pfizer, FibroGen, Aclaris and more

...the results with published natural history data. FibroGen presented the data on the mAb against CTGF...
...of GABRD are due by mid-2020 (see "Doing More With Less" ). Targets: CTGF - Connective tissue growth factor...
...l-1001, forigerimod) Pamrevlumab (FG-3019) Revatio, Viagra, sildenafil FibroGen Inc. ImmuPharma plc Jiangsu Hengrui Medicine Co. Ltd. Elevar Therapeutics Inc. Pfizer Inc. Alpha synuclein (SNCA) Connective tissue growth factor (CTGF) Vascular...
BioCentury | Aug 17, 2018
Clinical News

RXi's subretinal fibrosis therapy well tolerated in Phase I/II

...Marlborough, Mass. Product: RXI-109 Business: Ophthalmic Molecular target: Connective tissue growth factor (CTGF) Description: Self-delivering rxRNA (sd-rxRNA) compound targeting CTGF...
...angiography, and best corrected visual acuity (BCVA) Status: Phase I/II data Milestone: NA Sandi Wong RXI-109 Phio Pharmaceuticals Corp. Connective tissue growth factor (CTGF)...
BioCentury | Jul 20, 2018
Financial News

RNAi company OliX lists in Korea

...to treat hypertrophic scars. The RNA interference therapeutic targets connective tissue growth factor (CTGF). The company is also developing CTGF-targeted...
...and OLX701 to treat liver fibrosis. OliX Pharmaceuticals Inc. (KOSDAQ:226950), Suwon, Korea Jaime De Leon OLX201 OLX301 OliX Pharmaceuticals Inc. Connective tissue growth factor (CTGF) OLX10010 OLX701...
BioCentury | Jul 17, 2018
Financial News

RNAi company OliX lists in Korea

...to treat hypertrophic scars. The RNA interference therapeutic targets connective tissue growth factor (CTGF). The company is also developing CTGF-targeted...
...age-related macular degeneration and retinal fibrosis, and OLX701 to treat liver fibrosis. Jaime De Leon OLX201 OLX301 OliX Pharmaceuticals Inc. Connective tissue growth factor (CTGF) OLX10010 OLX701...
BioCentury | Jun 15, 2018
Clinical News

FibroGen's pamrevlumab improves survival in Phase I/II for pancreatic cancer

...Abraxane alone (33.3% vs. 7.7%) (see BioCentury, May 25) . Pamrevlumab, a human mAb against connective tissue growth factor (CTGF)...
...San Francisco, Calif. Product: Pamrevlumab (FG-3019) Business: Cancer Molecular target: Connective tissue growth factor (CTGF) Description: Human mAb against CTGF...
...survival (PFS) Status: Additional Phase I/II data Milestone: NA Sandi Wong Pamrevlumab (FG-3019) American Society of Clinical Oncology FibroGen Inc. Connective tissue growth factor (CTGF)...
BioCentury | Jun 5, 2018
Distillery Techniques

Assays and screens; imaging

...dubbed NanoFlare, utilizes a double-stranded oligonucleotide: the first strand is complementary to a sequence within connective tissue growth factor (CTGF)...
...fluorophore; the second strand is linked to a gold nanoparticle that quenches the fluorophore until CTGF...
...nanoparticles, followed by fluorescent imaging of the treated tissue, identifies tissues containing fibroblasts with high CTGF...
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