07:00 , Aug 4, 2016 |  BC Innovations  |  Product R&D

Antibiotic wisdom

While one of the biggest problems in infectious diseases is the overuse of antibiotics, few point-of-care tools are available to help physicians decide when and what to prescribe. Focusing on host genes rather than microbial...
08:00 , Jan 29, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Complement component 3a receptor 1 (C3AR1; C3AR); NF-κB; complement 3 (C3)

Neurology INDICATION: Alzheimer's disease (AD) In vitro and mouse studies suggest antagonizing C3AR could help treat AD. Abnormal NF-κB activation is associated with AD. In co-cultures of mouse astrocytes and normal mouse hippocampal neurons, astrocytes...
07:00 , Aug 7, 2014 |  BC Innovations  |  Targets & Mechanisms

Adipsin meets beta cells

The long-standing mystery of how adipsin regulates metabolism has been solved by a Harvard-led team that has shown the enzyme can increase insulin secretion by generating the peptide complement 3a . 1 Its therapeutic potential...
07:00 , Jun 20, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Ischemia/reperfusion injury Complement component 3a receptor 1 (C3AR1; C3AR) Mouse studies suggest C3AR agonists could help treat ischemia/reperfusion injury. In mice, C3ar knockout increased...
07:00 , Apr 9, 2009 |  BC Innovations  |  Cover Story

Opening up Rosetta

Merck & Co. Inc. 's soon-to-be shuttered Rosetta Inpharmatics Inc. unit is to be reborn as Sage , a not-for-profit institute that aims to provide precompetitive open access to the pharma's integrative genomics data set....
07:00 , Apr 9, 2009 |  BC Innovations  |  Distillery Therapeutics

This week in therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Metabolic disease Obesity Component 3a receptor 1 (C3AR1); transforming growth factor-b receptor II (TGFBR2); growth arrest-specific gene 7 (GAS7); glutathione peroxidase...