BioCentury | Oct 3, 2019
Targets & Mechanisms

ALS platform trial to put neuroinflammation hypothesis to the test

...and C5b. C5a recruits inflammatory cells like macrophages and neutrophils and activates mast cells, while C5b...
BioCentury | Jul 11, 2017
Emerging Company Profile

Complementary ALS play

...C5b . C5a recruits inflammatory cells like macrophages and neutrophils and activates mast cells, while C5b...
BioCentury | Aug 7, 2014
Targets & Mechanisms

Adipsin meets beta cells

...hydrolysis cascade that produces various complement fragments including complement 3a (C3a) , C3b, C5a and C5b...
BioCentury | Oct 29, 2012
Emerging Company Profile

Regenesance: Stopping the MAC attack

...recruit effectors that damage the neuromuscular junction. The primary effector is thought to be the C5b-9...
...for myasthenia gravis. The drug inhibits the cleavage of C5 into C5a and C5b. While C5b...
BioCentury | Dec 8, 2011
Cover Story

Big MAC attack in osteoarthritis

...fluid and membranes from healthy controls. These components included complement 5 (C5) and the complement C5b-9...
...C5 plays a role in inflammatory and cell-killing processes by cleaving into C5a and C5b...
...]. Upon cleavage from C5, C5b recruits other complement factors (C6-C9) to form the complement C5b-9...
BioCentury | Jan 30, 2006
Product Development

Indication finding

...ALXN's second product, pexelizumab, prevent C5 convertase from docking and converting C5 into C5a and C5b...
BioCentury | Oct 11, 2004
Product Development

The heart of inflammation

...chain monoclonal antibody, binds C5 and inhibits its cleavage by C5 convertase into C5a and C5b...
BioCentury | Feb 25, 2002
Product Development

Complementary difficulties

...of all four compounds is to inhibit the cleavage of complement C5 into C5a and C5b...
...molecular component of the C3 and C5 convertase, which cleaves C5 to produce C5a and C5b...
...to C5, preventing C5 convertase from docking to C5 and converting it into C5a and C5b...
BioCentury | Oct 9, 1995
Clinical News

Alexion preclinical data

...showed that the antibody fragment blocks the C5 complement protein from cleaving into C5a and C5b...
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