19:23 , May 6, 2019 |  BC Innovations  |  Distillery Therapeutics

Chlorobenzamide-based activator of SOD3 to treat osteoarthritis

DISEASE CATEGORY: Autoimmune disease INDICATION: Osteoarthritis Cell culture and rat studies identified a chlorobenzamide-based SOD3 activator that could help treat osteoarthritis (OA). Screening of a small molecule library in mouse chondrocyte-based activity assays yielded a...
18:28 , Nov 2, 2017 |  BC Innovations  |  Emerging Company Profile

Tougher Tregs

Casebia Therapeutics is using gene editing to engineer autologous Tregs with more durable immunosuppressive activity than unmodified Tregs, and plans to use the cells to treat a variety of autoimmune diseases. Casebia is a JV...
15:20 , Mar 21, 2017 |  BC Innovations  |  Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy An in vitro protocol could differentiate human MSCs into stable cartilage tissue for use in regenerative therapies. The protocol involves using a culture system of two compartments separated by a collagen-coated membrane...
08:00 , Mar 10, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Major histocompatibility complex class II (MHCII); glucose-6-phosphatase catalytic 2 (G6PC2; IGRP); proteolipid protein 1 (PLP1); myelin oligodend

Autoimmune disease INDICATION: Diabetes; rheumatoid arthritis (RA); multiple sclerosis (MS) Mouse studies suggest nanoparticles coated with MHCII molecules bound to disease-relevant peptides could help treat Type I diabetes, RA and MS. In a mouse model...
07:00 , Sep 21, 2015 |  BC Week In Review  |  Clinical News

TxCell preclinical data

In an animal model of non-infectious uveitis, IV Col-Treg significantly inhibited clinical symptoms, retinal tissue lesions and ocular proinflammatory cell infiltration. Data were published in Investigative Ophthalmology & Visual Science. Next year, TxCell plans to...
07:00 , Jul 30, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Myoglobin-surfactant complex for oxygenating large engineered tissue constructs

Drug platforms TECHNOLOGY: Cell therapy A myoglobin-surfactant complex could help oxygenate large tissue constructs engineered to repair or replace damaged tissue. The complex consisting of myoglobin conjugated to glycolic acid ethoxylate 4-nonylphenyl ether - an...
08:00 , Mar 3, 1997 |  BioCentury  |  Tools & Techniques

Cloning as an 'enabling experiment'; Identity of tantalizing cell remains hidden

As the rest of the world speculates about what the cloning of a single sheep may mean for humanity, the exclusive licensee to aspects of the technology responsible for this feat is working toward its...