14:20 , May 14, 2019 |  BC Innovations  |  Distillery Therapeutics

TRPC6 inhibitor for cardiac and renal fibrosis

DISEASE CATEGORY: Cardiovascular; renal INDICATION: Cardiovascular; renal Cell culture and mouse studies identified a trifluoromethylphenyl-based TRPC6 inhibitor that could help treat cardiac and renal fibrosis. High throughput screening of a small molecule library in cell-based...
21:03 , Jan 30, 2019 |  BC Innovations  |  Translation in Brief

Epigenetic links in endometriosis

An HDAC3-mediated epigenetic pathway could lead to new therapies and markers for endometriosis and associated infertility. Researchers from Michigan State University and Yonsei University College of Medicine have linked an epigenetic pathway involving HDAC3 to...
08:00 , Nov 21, 2013 |  BC Innovations  |  Targets & Mechanisms

Getting to the root of periodontitis

Current periodontitis therapies do not target the underlying immune response that drives the disease. A team from the U.S. and Brazil is looking to change that and has shown that microparticles loaded with chemokine CC...
07:00 , Mar 21, 2013 |  BC Innovations  |  Targets & Mechanisms

Understanding fibrosis

Researchers at The University of Alabama at Birmingham have identified idiopathic pulmonary fibrosis as a repurposing opportunity for fasudil, a Rho kinase inhibitor that Asahi Kasei Pharma Corp. markets as Eril to treat aneurysm. The...