BioCentury | Oct 2, 2020
Distillery Therapeutics

Blocking a lipid hydrolase for liver fibrosis

...analog reduced matrix stiffness in tissue and levels of two fibrosis markers, hepatic hydroxyproline and collagen...
...well as ACTA2 protein levels.TARGET/MARKER/PATHWAY: N-acylsphingosine amidohydrolase 1 (ASAH1); actin α 2 smooth aorta muscle (ACTA2; α-SMA); collagen...
BioCentury | Aug 28, 2020
Distillery Therapeutics

Repurposed integrin inhibitor for cardiac wound healing

...with classic Ehlers-Danlos syndrome, a connective tissue disorder caused by COL5 mutations.TARGET/MARKER/PATHWAY: Collagen type V (COL5); Collagen...
BioCentury | Aug 27, 2020
Distillery Therapeutics

siRNAs against plaque-destabilizing molecule CAMK2G for atherosclerosis

...mouse model of atherosclerosis, the nanoparticles reduced necrotic core area in atherosclerotic plaques and enhanced collagen...
BioCentury | Aug 27, 2020
Distillery Therapeutics

A collagen receptor as an Alzheimer’s target

...DISEASE CATEGORY: NeurologyINDICATION: Alzheimer’s disease (AD)Blocking the collagen...
...a generic AGTR1 antagonist previously shown to inhibit collagen-induced...
BioCentury | Jul 31, 2020
Distillery Therapeutics

Antisense-mediated exon skipping for X-linked Alport syndrome

...markers of blood urea nitrogen (BUN) and creatine. Ongoing work includes safety pharmacology studies. TARGET/MARKER/PATHWAY: Collagen...
...doi:10.1038/s41467-020-16605-x CONTACT: Kandai Nozu, Kobe University Graduate School of Medicine, Kobe, Japan email: nozu@med.kobe-u.ac.jp Claire Quang Kobe University Collagen...
BioCentury | Jul 23, 2020
Deals

July 22 Quick Takes: BioNTech raises $512M; plus Vesigen, Quantro, Cullinan, TransThera, JW-Syracuse, AnHeart-NewG

...Technology. The newco’s lead program combines two cytokines -- IL-12 and IL-2 -- with a collagen-binding...
BioCentury | Jun 26, 2020
Distillery Therapeutics

MAP3K7, IL18R1 as targets in obesity-related cerebrovascular dysfunction

...injection of a MAP3K7 inhibitor tool compound or an anti-IL18R1 antibody reduced the thickness and collagen...
BioCentury | Jun 24, 2020
Finance

AsclepiX aims for basket of retinal indications with $35M series A

...that are naturally occurring within the body,” Chairman Steven Altschuler added. AXT107 is derived from collagen...
BioCentury | May 14, 2020
Deals

With Northern Biologics deal, Boehringer adds pair of hot topics to its immuno-oncology basket

...so we will continue to look,” said Sedgwick. Breaking through The tumor stroma is a collagen...
BioCentury | May 1, 2020
Distillery Therapeutics

Disrupting hypoxia signaling to treat a muscular dystrophy

...swimming ability. Rapamycin and herbimycin also decreased the number of apoptotic muscle fibers and reduced collagen...
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