BioCentury | Jan 4, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: December 2017

...suggest HRK-based peptides could help treat scleroderma. Harvard Medical School Preclinical News Cancer Breast cancer Coiled-coil domain containing 88C...
BioCentury | Dec 5, 2017
Distillery Techniques

Chemistry

...the GNAI3 variant bound four GBA motif proteins -- coiled-coil domain containing 88B (CCDC88B; CCDC88), coiled-coil domain containing 88C...
...of Medicine, Boston, Mass. email: mgm1@bu.edu Hongjiang Li Boston University School of Medicine Coiled-coil domain containing 88B (CCDC88B) (CCDC88) Coiled-coil domain containing 88C...
BioCentury | Oct 24, 2017
Distillery Therapeutics

Autoimmune disease

INDICATION: Inflammatory bowel disease (IBD); Crohn's disease Patient sample and mouse studies suggest inhibiting CCDC88B could help treat IBD. In colon tissue samples from ulcerative colitis and Crohn’s disease patients, levels of CCDC88B mRNA and...
BioCentury | Oct 17, 2017
Preclinical News

Researchers identify CCDC88B as new target for IBD

In a paper published in Nature Communications , researchers at McGill University and others identified coiled-coil domain containing 88B ( CCDC88B ; CCDC88) as a potential target for inflammatory bowel disease. In a mouse model of dextran...
BioCentury | Jan 18, 2017
Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on four genes could help predict the risk of primary sclerosing cholangitis. Genome-wide association studies in a total of 4,796 primary sclerosing cholangitis patients and 19,955 healthy volunteers identified independent associations between...
BioCentury | Dec 11, 2014
Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammation Coiled-coil domain containing 88B (CCDC88B; CCDC88) In vitro and mouse studies suggest inhibiting CCDC88B could help treat inflammatory conditions such as cerebral malaria infection....
BioCentury | Feb 19, 2009
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Coiled-coil domain containing 88A (CCDC88A; GIV); Rho guanine nucleotide exchange factor (GEF; ARHGEF); G protein alpha inhibiting activity polypeptide...
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