...motif. In vitro , the GNAI3 variant bound four GBA motif proteins -- coiled-coil domain containing 88B (CCDC88B; CCDC88...
...with K d values of 0.24-2.38 µM. In a human breast cancer cell line overexpressing CCDC88B...
...Mikel Garcia-Marcos, Boston University School of Medicine, Boston, Mass. email: mgm1@bu.edu Hongjiang Li Boston University School of Medicine Coiled-coil domain containing 88B (CCDC88B) (CCDC88) Coiled-coil...

...samples from ulcerative colitis and Crohn’s disease patients, levels of CCDC88B mRNA and numbers of CCDC88B-positive...
...CCDC88B. Next steps could include identifying and testing CCDC88B inhibitors in models of IBD. TARGET/MARKER/PATHWAY: Coiled-coil domain containing 88B...
...steps could include identifying and testing CCDC88B inhibitors in models of IBD. TARGET/MARKER/PATHWAY: Coiled-coil domain containing 88B (CCDC88B; CCDC88...

...in Nature Communications , researchers at McGill University and others identified coiled-coil domain containing 88B ( CCDC88B ; CCDC88...
...colitis, the researchers observed increased levels of CCDC88B mRNA and protein expression and recruitment of CCDC88B-positive...
...and had significantly longer colons following colitis induction compared with mice with normal CCDC88B expression. CCDC88B...

...healthy volunteers identified independent associations between the disease and SNPs on four genes: FOXP1 (rs80060485), CCDC88B...
...Institute, Hinxton, U.K. email: ca3@sanger.ac.uk Hongjiang Li Mayo Clinic Wellcome Sanger Institute C-type lectin domain family 16 member A (CLEC16A) Coiled-coil domain containing 88B (CCDC88B) (CCDC88) Forkhead...

...and contact information Inflammation Inflammation Coiled-coil domain containing 88B (CCDC88B; CCDC88) In vitro and mouse studies suggest inhibiting CCDC88B...
...cerebral malaria infection. In a mouse model of Plasmodium berghei infection, a loss-of-function mutation in Ccdc88B...
...only wild-type Ccdc88B. Ongoing studies include validating the mechanism and testing druggable targets in the CCDC88B...