BioCentury | Jan 4, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: December 2017

New Therapeutic Targets and Biomarkers: December 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during December 2017. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Dec 5, 2017
Distillery Techniques

Chemistry

...motif. In vitro , the GNAI3 variant bound four GBA motif proteins -- coiled-coil domain containing 88B (CCDC88B; CCDC88...
...with K d values of 0.24-2.38 µM. In a human breast cancer cell line overexpressing CCDC88B...
...Mikel Garcia-Marcos, Boston University School of Medicine, Boston, Mass. email: mgm1@bu.edu Hongjiang Li Boston University School of Medicine Coiled-coil domain containing 88B (CCDC88B) (CCDC88) Coiled-coil...
BioCentury | Oct 24, 2017
Distillery Therapeutics

Autoimmune disease

...samples from ulcerative colitis and Crohn’s disease patients, levels of CCDC88B mRNA and numbers of CCDC88B-positive...
...CCDC88B. Next steps could include identifying and testing CCDC88B inhibitors in models of IBD. TARGET/MARKER/PATHWAY: Coiled-coil domain containing 88B...
...steps could include identifying and testing CCDC88B inhibitors in models of IBD. TARGET/MARKER/PATHWAY: Coiled-coil domain containing 88B (CCDC88B; CCDC88...
BioCentury | Oct 17, 2017
Preclinical News

Researchers identify CCDC88B as new target for IBD

...in Nature Communications , researchers at McGill University and others identified coiled-coil domain containing 88B ( CCDC88B ; CCDC88...
...colitis, the researchers observed increased levels of CCDC88B mRNA and protein expression and recruitment of CCDC88B-positive...
...and had significantly longer colons following colitis induction compared with mice with normal CCDC88B expression. CCDC88B...
BioCentury | Jan 18, 2017
Distillery Techniques

Biomarkers

...healthy volunteers identified independent associations between the disease and SNPs on four genes: FOXP1 (rs80060485), CCDC88B...
...Institute, Hinxton, U.K. email: ca3@sanger.ac.uk Hongjiang Li Mayo Clinic Wellcome Sanger Institute C-type lectin domain family 16 member A (CLEC16A) Coiled-coil domain containing 88B (CCDC88B) (CCDC88) Forkhead...
BioCentury | Dec 11, 2014
Distillery Therapeutics

Indication: Inflammation

...and contact information Inflammation Inflammation Coiled-coil domain containing 88B (CCDC88B; CCDC88) In vitro and mouse studies suggest inhibiting CCDC88B...
...cerebral malaria infection. In a mouse model of Plasmodium berghei infection, a loss-of-function mutation in Ccdc88B...
...only wild-type Ccdc88B. Ongoing studies include validating the mechanism and testing druggable targets in the CCDC88B...
BioCentury | Feb 19, 2009
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Coiled-coil domain containing 88A (CCDC88A; GIV); Rho guanine nucleotide exchange factor (GEF; ARHGEF); G protein alpha inhibiting activity polypeptide...
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