19:32 , Dec 5, 2017 |  BC Innovations  |  Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds A GNAI3-based inhibitor could help probe the role of GBA motif-containing proteins in cancer. The inhibitor, which competitively inhibits binding between wild-type GNAI3 and GBA motif proteins, is a GNAI3 variant containing...
18:59 , Oct 24, 2017 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Inflammatory bowel disease (IBD); Crohn's disease Patient sample and mouse studies suggest inhibiting CCDC88B could help treat IBD. In colon tissue samples from ulcerative colitis and Crohn’s disease patients, levels of CCDC88B mRNA and...
13:54 , Oct 17, 2017 |  BC Extra  |  Preclinical News

Researchers identify CCDC88B as new target for IBD

In a paper published in Nature Communications , researchers at McGill University and others identified coiled-coil domain containing 88B ( CCDC88B ; CCDC88) as a potential target for inflammatory bowel disease. In a mouse model...
19:14 , Jan 18, 2017 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on four genes could help predict the risk of primary sclerosing cholangitis. Genome-wide association studies in a total of 4,796 primary sclerosing cholangitis patients and 19,955 healthy volunteers identified independent associations between...
08:00 , Dec 11, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammation Coiled-coil domain containing 88B (CCDC88B; CCDC88) In vitro and mouse studies suggest inhibiting CCDC88B could help treat inflammatory conditions such as cerebral malaria infection....