BioCentury | Mar 20, 2018
Distillery Therapeutics
Infectious disease
...INDICATION: Gram-negative bacterial infection In vitro and cell culture studies identified triazolopyrimidinone- and azabenzimidazole-based bacterial coaD...
...coaD with IC 50 values of 37 nM and 56 nM, respectively, and Pseudomonas aeruginosa coaD...
...Novartis AG could include testing the compounds in animal models of Gram-negative bacterial infection. TARGET/MARKER/PATHWAY: Phosphopantetheine adenylyltransferase (coaD)...
...coaD with IC 50 values of 37 nM and 56 nM, respectively, and Pseudomonas aeruginosa coaD...
...Novartis AG could include testing the compounds in animal models of Gram-negative bacterial infection. TARGET/MARKER/PATHWAY: Phosphopantetheine adenylyltransferase (coaD)...
