BioCentury | Feb 21, 2018
Distillery Therapeutics

Cancer

...of CARM1 were higher in tumors than in normal ovarian epithelial cells, and the high CARM1...
...high levels of CARM1 compared with CARM1-knockout cells. In an orthotopic xenograft mouse model of CARM1-positive...
...cancer, GSK2816126 decreased tumor growth and increased survival compared with vehicle. Next steps include evaluating CARM1...
BioCentury | Feb 6, 2014
Distillery Therapeutics

Indication: Cancer

...member 1 (SMARCC1; BAF155); coactivator-associated arginine methyltransferase 1 (CARM1) In vitro and mouse studies suggest inhibiting BAF155 methylation by CARM1...
...metastatic breast cancer. In breast cancer cells, BAF155 was identified as a substrate of the CARM1...
...methylation-resistant BAF155 mutant prevented tumor growth in the lungs. Next steps include identifying inhibitors of CARM1-mediated...
BioCentury | Apr 15, 2013
Company News

Senetek management update

Senetek PLC (SNTKY), New York, N.Y. Business: Reproductive Promoted: Cliff Brune as group president and COO, while remaining CFO; David Carey as VP of finance, formerly VP of finance for SNTKY's Carme Cosmeceutical Sciences Corp....
BioCentury | Apr 15, 2013
Clinical News

Kinetin N6-furfuryladenine plant growth hormone data

SNTKY announced results of a study in 64 subjects with mild to moderate photodamage to facial skin. Subjects applied either 0 percent or 0.005 percent kinetin in lotion twice daily for 24 weeks. They were...
BioCentury | Oct 20, 2011
Distillery Techniques

Technology: Assays & screens

...small molecule Hsp90 inhibitor PU-H71 bound to Hsp90 in complex with known oncogenic proteins and coactivator-associated arginine methyltransferase 1 (CARM1)...
...unlabeled control beads did not. In a CML cell line, small hairpin RNA-mediated knockdown of CARM1...
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