07:00 , Jul 9, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: clpP

Cancer INDICATION: Acute myelogenous leukemia (AML) In vitro and mouse studies suggest inhibiting clpP could help treat a subset of AML. Levels of the mitochondrial proteome protein clpP were higher in 45% of 511 AML...
08:00 , Dec 12, 2013 |  BC Innovations  |  Targets & Mechanisms

ClpPing persistence

Northeastern University researchers have combined traditional antibiotics with compounds that activate bacterial clpP protease and cured mice with severe, highly drug-resistant Staphylococcus biofilm infections. 1 Arietis Corp. is developing analogs of the compounds to treat...
08:00 , Dec 12, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Staphylococcus ClpP Cell culture and mouse studies suggest combining the antibiotic acyldepsipeptide 4 (ADEP4) with rifampicin could help eradicate biofilms....
07:00 , Oct 13, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Bacterial infection ATP-dependent Clp protease proteolytic subunit (clpP) In vitro studies identified clpP activators that could help treat bacterial infections. In a high throughput...